PDB entry 3ow3
View 3ow3 on RCSB PDB site
Description: Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
Class: TRANSFERASE/TRANSFERASE inhibitor
Keywords: cyclic-AMP dependent protein kinase, TRANSFERASE-TRANSFERASE inhibitor complex
Deposited on
2010-09-17, released
2010-11-10
The last revision prior to the SCOPe 2.08 freeze date was dated
2010-11-24, with a file datestamp of
2010-11-19.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.166
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cAMP-dependent protein kinase catalytic subunit alpha
Species: Mus musculus [TaxId:10090]
Gene: Prkaca, Pkaca
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3ow3a_ - Chain 'B':
Compound: cAMP-dependent protein kinase inhibitor alpha
Species: MUS MUSCULUS, synthetic [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Heterogens: SMY, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3ow3A (A:)
gnaaaakkgseqesvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlv
khkesgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvaggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef
Sequence, based on observed residues (ATOM records): (download)
>3ow3A (A:)
vkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamkil
dkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshlrr
igrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkgr
twtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgk
vrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapf
ipkfkgpgdtsnfddyeeeeirvsinekcgkeftef
- Chain 'B':
No sequence available.