PDB entry 3op5

View 3op5 on RCSB PDB site
Description: Human vaccinia-related kinase 1
Class: transferase
Keywords: Adenosine Triphosphate, Amino Acid Sequence, Binding Sites, Catalytic Domain, Models, Molecular, Molecular Sequence Data, Phosphotransferases, Protein Conformation, Protein Folding, Surface Entropy Reduction, Structural Genomics, Structural Genomics Consortium, SGC, transferase
Deposited on 2010-08-31, released 2010-09-22
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-08-29, with a file datestamp of 2012-08-24.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.179
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase VRK1
    Species: Homo sapiens [TaxId:9606]
    Gene: VRK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99986
      • engineered mutation (33-35)
      • engineered mutation (211)
      • engineered mutation (213-214)
      • engineered mutation (291-292)
      • engineered mutation (294)
    Domains in SCOPe 2.05: d3op5a_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase VRK1
    Species: Homo sapiens [TaxId:9606]
    Gene: VRK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99986
      • engineered mutation (33-35)
      • engineered mutation (211)
      • engineered mutation (213-214)
      • engineered mutation (291-292)
      • engineered mutation (294)
    Domains in SCOPe 2.05: d3op5b_
  • Chain 'C':
    Compound: Serine/threonine-protein kinase VRK1
    Species: Homo sapiens [TaxId:9606]
    Gene: VRK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99986
      • engineered mutation (33-35)
      • engineered mutation (211)
      • engineered mutation (213-214)
      • engineered mutation (291-292)
      • engineered mutation (294)
    Domains in SCOPe 2.05: d3op5c_
  • Chain 'D':
    Compound: Serine/threonine-protein kinase VRK1
    Species: Homo sapiens [TaxId:9606]
    Gene: VRK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99986
      • engineered mutation (33-35)
      • engineered mutation (211)
      • engineered mutation (213-214)
      • engineered mutation (291-292)
      • engineered mutation (294)
    Domains in SCOPe 2.05: d3op5d_
  • Heterogens: REB, EDO, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3op5A (A:)
smrvkaaqagrqssakrhlaeqfavgeiitdmaaaawkvglpigqggfgciyladmnsse
svgsdapcvvkvepsdngplftelkfyqraakpeqiqkwirtrklkylgvpkywgsglhd
kngksyrfmimdrfgsdlqkiyeanakrfsrktvlqlslrildileyiheheyvhgdika
snlllnyknpdqvylvdyglayrycpegvhkayaadpkrchdgtieftsidahngvapsr
rgdleilgycmiqwltghlpwednlkdpkyvrdskiryreniaslmdkcfpaanapgeia
kymetvklldytekplyenlrdillqglkaigskddgkldlsvvengglkaktitkkraa
eiee

    Sequence, based on observed residues (ATOM records): (download) 
    >3op5A (A:)
eqfavgeiitdmaaaawkvglpigqgfgciyladmnssesvgsdapcvvkvepsdngplf
telkfyqraakpeqiqkwirtrklkylgvpkywgsglhdkngksyrfmimdrfgsdlqki
yeanakrfsrktvlqlslrildileyiheheyvhgdikasnlllnyknpdqvylvdygla
yrycpegvhkayaadpkrchdgtieftsidahngvapsrrgdleilgycmiqwltghlpw
ednlkdpkyvrdskiryreniaslmdkcfpaanapgeiakymetvklldytekplyenlr
dillqglkaigskddgkldl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3op5B (B:)
smrvkaaqagrqssakrhlaeqfavgeiitdmaaaawkvglpigqggfgciyladmnsse
svgsdapcvvkvepsdngplftelkfyqraakpeqiqkwirtrklkylgvpkywgsglhd
kngksyrfmimdrfgsdlqkiyeanakrfsrktvlqlslrildileyiheheyvhgdika
snlllnyknpdqvylvdyglayrycpegvhkayaadpkrchdgtieftsidahngvapsr
rgdleilgycmiqwltghlpwednlkdpkyvrdskiryreniaslmdkcfpaanapgeia
kymetvklldytekplyenlrdillqglkaigskddgkldlsvvengglkaktitkkraa
eiee

    Sequence, based on observed residues (ATOM records): (download) 
    >3op5B (B:)
eqfavgeiitdmaaaawkvglpigqfgciyladmnssesvgsdapcvvkvepsdngplft
elkfyqraakpeqiqkwirtrklkylgvpkywgsglhdkngksyrfmimdrfgsdlqkiy
eanakrfsrktvlqlslrildileyiheheyvhgdikasnlllnyknpdqvylvdyglay
rycpegvhkayaadpkrchdgtieftsidahngvapsrrgdleilgycmiqwltghlpwe
dnlkdpkyvrdskiryreniaslmdkcfpaanapgeiakymetvklldytekplyenlrd
illqglkaigskddgkldl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3op5C (C:)
smrvkaaqagrqssakrhlaeqfavgeiitdmaaaawkvglpigqggfgciyladmnsse
svgsdapcvvkvepsdngplftelkfyqraakpeqiqkwirtrklkylgvpkywgsglhd
kngksyrfmimdrfgsdlqkiyeanakrfsrktvlqlslrildileyiheheyvhgdika
snlllnyknpdqvylvdyglayrycpegvhkayaadpkrchdgtieftsidahngvapsr
rgdleilgycmiqwltghlpwednlkdpkyvrdskiryreniaslmdkcfpaanapgeia
kymetvklldytekplyenlrdillqglkaigskddgkldlsvvengglkaktitkkraa
eiee

    Sequence, based on observed residues (ATOM records): (download) 
    >3op5C (C:)
qfavgeiitdmaaaawkvglpigqggciyladmnssesdapcvvkvelftelkfyqraak
peqiqkwirtrklkylgvpkywgsglhdknksyrfmimdrfgsdlqkiyeanakrfsrkt
vlqlslrildileyiheheyvhgdikasnlllnyknpdqvylvdyglayrycpegvhkay
aadpkrchdgtieftsidahngvapsrrgdleilgycmiqwltghlpwednlkdpkyvrd
skiryreniaslmdkcfpaanapgeiakymetvklldytekplyenlrdillqglkaigs
kddgkldl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3op5D (D:)
smrvkaaqagrqssakrhlaeqfavgeiitdmaaaawkvglpigqggfgciyladmnsse
svgsdapcvvkvepsdngplftelkfyqraakpeqiqkwirtrklkylgvpkywgsglhd
kngksyrfmimdrfgsdlqkiyeanakrfsrktvlqlslrildileyiheheyvhgdika
snlllnyknpdqvylvdyglayrycpegvhkayaadpkrchdgtieftsidahngvapsr
rgdleilgycmiqwltghlpwednlkdpkyvrdskiryreniaslmdkcfpaanapgeia
kymetvklldytekplyenlrdillqglkaigskddgkldlsvvengglkaktitkkraa
eiee

    Sequence, based on observed residues (ATOM records): (download) 
    >3op5D (D:)
vgeiitdmaaaawkvglpiciyladmnssdapcvvkvepsplftelkfyqraakpeqiqk
wirtrklkylgvpkywgsglhdngksyrfmimdrfgsdlqkiyeanakrfsrktvlqlsl
rildileyiheheyvhgdikasnlllnyknpdqvylvdyglayrycpegvhkayaadpkr
chdgtieftsidahngvapsrrgdleilgycmiqwltghlpwednlkdpkyvrdskiryr
eniaslmdkcfpaanapgeiakymetvklldytekplyenlrdillqglkaigskddgkl
dl