PDB entry 3ojm
View 3ojm on RCSB PDB site
Description: Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation
Class: Cytokine/Signaling Protein
Keywords: beta trefoil motif, immunoglobulin-like domain, growth factor, growth factor receptor, extracellular, Cytokine-Signaling Protein complex
Deposited on
2010-08-23, released
2011-08-31
The last revision prior to the SCOPe 2.03 freeze date was dated
2012-03-07, with a file datestamp of
2012-03-02.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.229
AEROSPACI score: 0.39
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: heparin-binding growth factor 1
Species: Homo sapiens [TaxId:9606]
Gene: FGF1, FGFA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3ojma_ - Chain 'B':
Compound: Fibroblast growth factor receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: BEK, FGFR2, KGFR, KSAM
Database cross-references and differences (RAF-indexed):
- Uniprot P21802 (Start-174)
- engineered mutation (114)
- see remark 999 (175-222)
Domains in SCOPe 2.03: d3ojmb1, d3ojmb2 - Heterogens: SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3ojmA (A:)
maegeittftaltekfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlq
lsaesvgevyikstetgqylamdtdgllygsqtpneeclflerleenhyntyiskkhaek
nwfvglkkngsckrgprthygqkailflplpvssd
Sequence, based on observed residues (ATOM records): (download)
>3ojmA (A:)
taltekfnlppgnykkpkllycsngghflrilpdgtvdgtrdrsdqhiqlqlsaesvgev
yikstetgqylamdtdgllygsqtpneeclflerleenhyntyiskkhaeknwfvglkkn
gsckrgprthygqkailflplpvss
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3ojmB (B:)
maedfvsensnnkrapywtntekmekrlhavpaantvkfrcpaggnpmptmrwlkngkef
kqehriggykvrnqhwslimesvvpsdkgnytcvveneygsinhtyhldvversrhrpil
qaglpanastvvggdvefvckvysdaqphiqwikhvekngskygpdglpylkvlkhsgin
ssnaevlalfnvteadageyickvsnyigqanqsawltvlpkqqapgreke
Sequence, based on observed residues (ATOM records): (download)
>3ojmB (B:)
krapywtntekmekrlhavpaantvkfrcpaggnpmptmrwlkngkefkqehriggykvr
nqhwslimesvvpsdkgnytcvveneygsinhtyhldvversrhrpilqaglpanastvv
ggdvefvckvysdaqphiqwikhvekngskygpdglpylkvlkhsginssnaevlalfnv
teadageyickvsnyigqanqsawltvlpkq