SCOPe 2.08: Structural Classification of Proteins

PDB entry 3ofs

View 3ofs on RCSB PDB site
Description: Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy crystallography
Class: hydrolase
Keywords: CD38, cyclization, hydrolysis, cADPR, ADPR, ara-2'F-NAD, ara-2'F-ADPR, hydrolase
Deposited on 2010-08-16, released 2010-12-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: ADP-ribosyl cyclase 1
Species: Homo sapiens [TaxId:9606]
Gene: CD38
Database cross-references and differences (RAF-indexed):
- Uniprot P28907 (2-End)
  - engineered mutation (5)
  - engineered mutation (56)
  - engineered mutation (102)
  - engineered mutation (120)
  - engineered mutation (165)
  - engineered mutation (175)
Domains in SCOPe 2.08: d3ofsa_
Chain 'B':
Compound: ADP-ribosyl cyclase 1
Species: Homo sapiens [TaxId:9606]
Gene: CD38
Database cross-references and differences (RAF-indexed):
- Uniprot P28907 (2-End)
  - engineered mutation (5)
  - engineered mutation (56)
  - engineered mutation (102)
  - engineered mutation (120)
  - engineered mutation (165)
  - engineered mutation (175)
Domains in SCOPe 2.08: d3ofsb_
Chain 'C':
Compound: ADP-ribosyl cyclase 1
Species: Homo sapiens [TaxId:9606]
Gene: CD38
Database cross-references and differences (RAF-indexed):
- Uniprot P28907 (2-End)
  - engineered mutation (5)
  - engineered mutation (56)
  - engineered mutation (102)
  - engineered mutation (120)
  - engineered mutation (165)
  - engineered mutation (175)
Domains in SCOPe 2.08: d3ofsc_
Chain 'D':
Compound: ADP-ribosyl cyclase 1
Species: Homo sapiens [TaxId:9606]
Gene: CD38
Database cross-references and differences (RAF-indexed):
- Uniprot P28907 (2-End)
  - engineered mutation (5)
  - engineered mutation (56)
  - engineered mutation (102)
  - engineered mutation (120)
  - engineered mutation (165)
  - engineered mutation (175)
Domains in SCOPe 2.08: d3ofsd_
Chain 'E':
Compound: ADP-ribosyl cyclase 1
Species: Homo sapiens [TaxId:9606]
Gene: CD38
Database cross-references and differences (RAF-indexed):
- Uniprot P28907 (2-End)
  - engineered mutation (5)
  - engineered mutation (56)
  - engineered mutation (102)
  - engineered mutation (120)
  - engineered mutation (165)
  - engineered mutation (175)
Domains in SCOPe 2.08: d3ofse_
Chain 'F':
Compound: ADP-ribosyl cyclase 1
Species: Homo sapiens [TaxId:9606]
Gene: CD38
Database cross-references and differences (RAF-indexed):
- Uniprot P28907 (2-End)
  - engineered mutation (5)
  - engineered mutation (56)
  - engineered mutation (102)
  - engineered mutation (120)
  - engineered mutation (165)
  - engineered mutation (175)
Domains in SCOPe 2.08: d3ofsf_
Heterogens: AVU, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3ofsA (A:)
efwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftladtllgyladdltwcgef
dtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdk
flqcvknpedssctsei