PDB entry 3oct

View 3oct on RCSB PDB site
Description: Crystal structure of bruton's tyrosine kinase mutant V555R in complex with dasatinib
Class: transferase/transferase inhibitor
Keywords: tyrosine kinase, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-08-10, released 2010-11-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2010-11-17, with a file datestamp of 2010-11-12.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.199
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3octa_
  • Heterogens: 1N1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3octA (A:)
    ggsweidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmn
    lsheklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceamey
    leskqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssrgskfpvrwsppevlmy
    skfssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimy
    scwhekaderptfkillsnildvmd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3octA (A:)
    sweidpkdltflkelgqfgvvkygkwrgqydvaikmikmsedefieeakvmmnlsheklv
    qlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyleskqfl
    hrdlaarnclvndqgvvkvsdfglsrfpvrwsppevlmyskfssksdiwafgvlmweiys
    lgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwhekaderptfkillsnil
    dvmd