PDB entry 3ob7

View 3ob7 on RCSB PDB site
Description: Human Thymidylate Synthase R163K with Cys 195 covalently modified by Glutathione
Class: transferase
Keywords: methyltransferase, TRANSFERASE
Deposited on 2010-08-06, released 2010-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (162)
    Domains in SCOPe 2.08: d3ob7a_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (162)
    Domains in SCOPe 2.08: d3ob7b_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (162)
    Domains in SCOPe 2.08: d3ob7c_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (162)
    Domains in SCOPe 2.08: d3ob7d_
  • Chain 'E':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (162)
    Domains in SCOPe 2.08: d3ob7e_
  • Heterogens: GSH, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ob7A (A:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqkvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >3ob7A (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ob7B (B:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqkvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >3ob7B (B:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3ob7C (C:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqkvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >3ob7C (C:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3ob7D (D:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqkvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >3ob7D (D:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3ob7E (E:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqkvidtiktnpddrriimc
awnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >3ob7E (E:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqkvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphp