PDB entry 3o8a

View 3o8a on RCSB PDB site
Description: Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348
Class: oxidoreductase
Keywords: alpha beta fold, dihydroorotate dehydrogenase, Oxidoreductase, Pyrimidine biosynthesis, Genz667348, FAD, Flavoprotein, Mitochondrion inner membrane
Deposited on 2010-08-02, released 2010-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-23, with a file datestamp of 2017-08-18.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase homolog, mitochondrial
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: dihydroorotate dehydrogenase, PFF0160c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3o8aa_
  • Heterogens: O8A, FMN, ORO, LDA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3o8aA (A:)
mgsshhhhhhssglvprgshmasmtggqqgrdpfesynpefflydiflkfclkyidgeic
hdlflllgkynilpydtsndsiyactnikhldfinpfgvaagfdkngvcidsilklgfsf
ieigtitprgqtgnakprifrdvesrsiinscgfnnmgcdkvtenlilfrkrqeedklls
khivgvsigknkdtvnivddlkycinkigryadyiainvsspntpglrdnqeagklknii
lsvkeeidnleknnimndeflwfnttkkkplvfvklapdlnqeqkkeiadvlletnidgm
iisntttqindiksfenkkggvsgaklkdistkficemynytnkqipiiasggifsglda
lekieagasvcqlysclvfngmksavqikrelnhllyqrgyynlkeaigrkhsks

    Sequence, based on observed residues (ATOM records): (download) 
    >3o8aA (A:)
ynpefflydiflkfclkyidgeichdlflllgkynilpydtsndsiyactnikhldfinp
fgvaagfdkngvcidsilklgfsfieigtitprgqtgnakprifrdvesrsiinscgfnn
mgcdkvtenlilfrkrqeedkllskhivgvsigknkdtvnivddlkycinkigryadyia
invsspntpglrdnqeagklkniilsvkeeidnleknnimndeflwfnttkkkplvfvkl
apdlnqeqkkeiadvlletnidgmiisntttqindiksfenkkggvsgaklkdistkfic
emynytnkqipiiasggifsgldalekieagasvcqlysclvfngmksavqikrelnhll
yqrgyynlkeaigrk