PDB entry 3o6f

View 3o6f on RCSB PDB site
Description: Crystal structure of a human autoimmune TCR MS2-3C8 bound to MHC class II self-ligand MBP/HLA-DR4
Class: immune system
Keywords: Autoimmunity, Multiple sclerosis, T cell receptor, HLA class II, protein-protein complex, Immunoglobulin fold, Membrane, IMMUNE SYSTEM
Deposited on 2010-07-29, released 2011-03-02
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-09-07, with a file datestamp of 2011-09-02.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.239
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3o6fa1, d3o6fa2
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DRB1-4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed):
    • PDB 3O6F (0-End)
    • Uniprot P13760 (30-End)
  • Chain 'C':
    Compound: T-cell receptor alpha chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: TRAC, TCRA
    Database cross-references and differences (RAF-indexed):
    • PDB 3O6F (Start-109)
    • Uniprot P01848 (110-End)
    Domains in SCOPe 2.06: d3o6fc1, d3o6fc2
  • Chain 'D':
    Compound: T-cell receptor beta-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: TRBC1
    Database cross-references and differences (RAF-indexed):
    • PDB 3O6F (0-114)
    • Uniprot A0A5B9 (115-244)
      • engineered mutation (188)
    Domains in SCOPe 2.06: d3o6fd1, d3o6fd2
  • Chain 'E':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3o6fe1, d3o6fe2
  • Chain 'F':
    Compound: HLA class II histocompatibility antigen, DRB1-4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed):
    • PDB 3O6F (0-29)
    • Uniprot P13760 (30-End)
  • Chain 'G':
    Compound: T-cell receptor alpha chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: TRAC, TCRA
    Database cross-references and differences (RAF-indexed):
    • PDB 3O6F (Start-109)
    • Uniprot P01848 (110-End)
    Domains in SCOPe 2.06: d3o6fg1, d3o6fg2
  • Chain 'H':
    Compound: T-cell receptor beta-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: TRBC1
    Database cross-references and differences (RAF-indexed):
    • PDB 3O6F (0-114)
    • Uniprot A0A5B9 (115-End)
      • engineered mutation (188)
    Domains in SCOPe 2.06: d3o6fh1, d3o6fh2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3o6fA (A:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >3o6fA (A:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3o6fC (C:)
gdakttqpnsmesneeepvhlpcnhstisgtdyihwyrqlpsqgpeyvihgltsnvnnrm
aslaiaedrksstlilhratlrdaavyyctvyggatnklifgtgtllavqpniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdktvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffpspessc

    Sequence, based on observed residues (ATOM records): (download) 
    >3o6fC (C:)
akttqpnsmesneeepvhlpcnhstisgtdyihwyrqlpsqgpeyvihgltsnvnnrmas
laiaedrksstlilhratlrdaavyyctvyggatnklifgtgtllavqpniqnpdpavyq
lrdskssdkvclftdfdsqtnvsskdsdvyitdktvldmrsmdfksnsavawsnksdfac
annsiipedtf

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3o6fD (D:)
vvsqhpswviaksgtsvkiecrsldfqattmfwyrqfpkqslmlmatsnegskatyeqgv
ekdkflinhasltlstltvtsahpedssfyicsarggsynsplhfgngtrltvtedlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeq
palndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gradc

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3o6fE (E:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >3o6fE (E:)
keehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgala
niavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtw
lrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3o6fG (G:)
gdakttqpnsmesneeepvhlpcnhstisgtdyihwyrqlpsqgpeyvihgltsnvnnrm
aslaiaedrksstlilhratlrdaavyyctvyggatnklifgtgtllavqpniqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdktvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffpspessc

    Sequence, based on observed residues (ATOM records): (download) 
    >3o6fG (G:)
akttqpnsmesneeepvhlpcnhstisgtdyihwyrqlpsqgpeyvihgltsnvnnrmas
laiaedrksstlilhratlrdaavyyctvyggatnklifgtgtllavqpniqnpdpavyq
lrdskssdkvclftdfdsqtnvsqdvyitdktvldmrsmdfksnsavawsnksdfacann
siipedtf

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3o6fH (H:)
vvsqhpswviaksgtsvkiecrsldfqattmfwyrqfpkqslmlmatsnegskatyeqgv
ekdkflinhasltlstltvtsahpedssfyicsarggsynsplhfgngtrltvtedlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeq
palndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gradc

    Sequence, based on observed residues (ATOM records): (download) 
    >3o6fH (H:)
vvsqhpswviaksgtsvkiecrsldfqattmfwyrqfpkqslmlmatsnegskatyeqgv
ekdkflinhasltlstltvtsahpedssfyicsarggsynsplhfgngtrltvtedlknv
fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeq
palndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
gra