PDB entry 3o64

View 3o64 on RCSB PDB site
Description: Crystal structure of catalytic domain of TACE with 2-(2-Aminothiazol-4-yl)pyrrolidine-Based Tartrate Diamides
Class: hydrolase/hydrolase inhibitor
Keywords: Hydrolase, ADAM Proteins, Enzyme Inhibitors, hydrolase-hydrolase inhibitor complex
Deposited on 2010-07-28, released 2011-04-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-05-18, with a file datestamp of 2011-05-13.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: 0.188
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tace
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM17, CSVP, TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered mutation (51)
      • engineered mutation (138)
      • engineered mutation (237)
    Domains in SCOPe 2.08: d3o64a_
  • Chain 'B':
    Compound: tace
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM17, CSVP, TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered mutation (51)
      • engineered mutation (138)
      • engineered mutation (237)
    Domains in SCOPe 2.08: d3o64b_
  • Heterogens: IPA, INN, ZN, CA, 786, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3o64A (A:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3o64A (A:)
dpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgyg
iqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclah
lftyqdfdmgtlglaygghggvcpkayyspvgkkniylnsgltstknygktiltkeadlv
tthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiykti
eskaqecfqers

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3o64B (B:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3o64B (B:)
mkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiqie
qirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlfty
qdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygktiltkead
lvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiyk
tieskaqecfqer