PDB entry 3o5x

View 3o5x on RCSB PDB site
Description: Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor
Class: hydrolase
Keywords: SHP2-IIB-08 complex, inhibitor, binding affinity, binding selectivity, receptor, Hydrolase, Dephosphorylation
Deposited on 2010-07-28, released 2010-08-11
The last revision prior to the SCOPe 2.04 freeze date was dated 2010-08-11, with a file datestamp of 2010-08-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.196
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3o5xa_
  • Heterogens: JZG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3o5xA (A:)
mlysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnn
skpkksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkey
gvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfle
evhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsq
rsgmvqteaqyrfiymavqhyietlqrrlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3o5xA (A:)
lysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvsdyinaniimpkksyiatqg
clqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesa
ahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimda
gpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyr
fiymavqhyietlqr