PDB entry 3nx0
View 3nx0 on RCSB PDB site
Description: Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C
Class: hydrolase inhibitor
Keywords: cysteine protease inhibitor, 3D domain swapping, protein engineering, protein oligomerization, protein aggregation, amyloid, HYDROLASE INHIBITOR
Deposited on
2010-07-12, released
2010-12-01
The last revision prior to the SCOPe 2.03 freeze date was dated
2011-03-02, with a file datestamp of
2011-02-25.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: 0.181
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cystatin-C
Species: Homo sapiens [TaxId:9606]
Gene: CST3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3nx0a_ - Chain 'B':
Compound: Cystatin-C
Species: Homo sapiens [TaxId:9606]
Gene: CST3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3nx0b_ - Heterogens: SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3nx0A (A:)
sspgkpprlvggpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqinagv
nyfldvelgrttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda
Sequence, based on observed residues (ATOM records): (download)
>3nx0A (A:)
gpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqinagvnyfldvelgrt
tctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3nx0B (B:)
sspgkpprlvggpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqinagv
nyfldvelgrttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda
Sequence, based on observed residues (ATOM records): (download)
>3nx0B (B:)
gpmdasveeegvrraldfavgeynkasndmyhsralqvvrarkqinagvnyfldvelgrt
tctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda