PDB entry 3nw2

View 3nw2 on RCSB PDB site
Description: Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights
Class: OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor
Keywords: CALMODULIN-BINDING, FAD, FMN, IRON, METAL-BINDING, NADP, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex
Deposited on 2010-07-09, released 2011-06-22
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-12-21, with a file datestamp of 2011-12-16.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.279
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nitric oxide synthase, inducible
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3nw2a_
  • Chain 'B':
    Compound: Nitric oxide synthase, inducible
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3nw2b_
  • Heterogens: HEM, H4B, SO4, MPW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3nw2A (A:)
qyvriknwgsgeilhdtlhhkatsdftcksksclgsimnpksltrgprdkptpleellph
aiefinqyygsfkeakieehlarleavtkeiettgtyqltldelifatkmawrnaprcig
riqwsnlqvfdarncstaqemfqhicrhilyatnngnirsaitvfpqrsdgkhdfrlwns
qliryagyqmpdgtirgdaatleftqlcidlgwkprygrfdvlplvlqadgqdpevfeip
pdlvlevtmehpkyewfqelglkwyalpavanmllevgglefpacpfngwymgteigvrd
fcdtqrynileevgrrmglethtlaslwkdravteinvavlhsfqkqnvtimdhhtases
fmkhmqneyrarggcpadwiwlvppvsgsitpvfhqemlnyvlspfyyyqiepwkthiwq
nek

    Sequence, based on observed residues (ATOM records): (download) 
    >3nw2A (A:)
qyvriknwgsgeilhdtlhhkatsdsclgsimnpksltrgprdkptpleellphaiefin
qyygsfkeakieehlarleavtkeiettgtyqltldelifatkmawrnaprcigriqwsn
lqvfdarncstaqemfqhicrhilyatnngnirsaitvfpqrsdgkhdfrlwnsqlirya
gyqmpdgtirgdaatleftqlcidlgwkprygrfdvlplvlqadgqdpevfeippdlvle
vtmehpkyewfqelglkwyalpavanmllevgglefpacpfngwymgteigvrdfcdtqr
ynileevgrrmglethtlaslwkdravteinvavlhsfqkqnvtimdhhtasesfmkhmq
neyrarggcpadwiwlvppvsgsitpvfhqemlnyvlspfyyyqiepwkthiwq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3nw2B (B:)
qyvriknwgsgeilhdtlhhkatsdftcksksclgsimnpksltrgprdkptpleellph
aiefinqyygsfkeakieehlarleavtkeiettgtyqltldelifatkmawrnaprcig
riqwsnlqvfdarncstaqemfqhicrhilyatnngnirsaitvfpqrsdgkhdfrlwns
qliryagyqmpdgtirgdaatleftqlcidlgwkprygrfdvlplvlqadgqdpevfeip
pdlvlevtmehpkyewfqelglkwyalpavanmllevgglefpacpfngwymgteigvrd
fcdtqrynileevgrrmglethtlaslwkdravteinvavlhsfqkqnvtimdhhtases
fmkhmqneyrarggcpadwiwlvppvsgsitpvfhqemlnyvlspfyyyqiepwkthiwq
nek

    Sequence, based on observed residues (ATOM records): (download) 
    >3nw2B (B:)
qyvriknwgsgeilhdtlhhkatssclgsimnpksltrgprdkptpleellphaiefinq
yygsfkeakieehlarleavtkeiettgtyqltldelifatkmawrnaprcigriqwsnl
qvfdarncstaqemfqhicrhilyatnngnirsaitvfpqrsdgkhdfrlwnsqliryag
yqmpdgtirgdaatleftqlcidlgwkprygrfdvlplvlqadgqdpevfeippdlvlev
tmehpkyewfqelglkwyalpavanmllevgglefpacpfngwymgteigvrdfcdtqry
nileevgrrmglethtlaslwkdravteinvavlhsfqkqnvtimdhhtasesfmkhmqn
eyrarggcpadwiwlvppvsgsitpvfhqemlnyvlspfyyyqiepwkthiwq