PDB entry 3nu0
View 3nu0 on RCSB PDB site
Description: Design, Synthesis, Biological Evaluation and X-ray Crystal Structure of Novel Classical 6,5,6-TricyclicBenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: dihydrofolate reductase, cyclized inhibitors, OXIDOREDUCTASE hDHFR-264-NADPH, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on
2010-07-06, released
2011-05-25
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-08, with a file datestamp of
2017-11-03.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: N/A
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Dihydrofolate reducatase
Species: Homo sapiens [TaxId:9606]
Gene: DHFR, DHFRP1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3nu0a_ - Heterogens: NDP, 3TU, SO4, HOH