PDB entry 3nps

View 3nps on RCSB PDB site
Description: Crystal structure of membrane-type serine protease 1 (MT-SP1) in complex with the Fab Inhibitor S4
Class: hydrolase/immune system
Keywords: hydrolase, Antibody-Protease Complex, Protein-Protein Complex, Enzyme-Inhibitor Complex, Disease mutation, Glycoprotein, Membrane, Serine protease, Signal-anchor, Transmembrane, HYDROLASE - IMMUNE SYSTEM complex, HYDROLASE-IMMUNE SYSTEM complex
Deposited on 2010-06-29, released 2011-07-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Suppressor of tumorigenicity 14 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS14, SNC19, ST14, TADG15
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y5Y6 (0-240)
      • engineered mutation (116)
    Domains in SCOPe 2.07: d3npsa_
  • Chain 'B':
    Compound: s4 fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3NPS (0-225)
  • Chain 'C':
    Compound: s4 fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3NPS (0-210)
    Domains in SCOPe 2.07: d3npsc1, d3npsc2
  • Heterogens: EDO, NA, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3npsA (A:)
    vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
    flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpislpd
    ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
    sggvdscqgdsggplssveadgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentg
    v
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3npsC (C:)
    vltqppsvsgapgqrvtiscsgsssnigsnyvswyqqkpgtapklliydnnqrpsgvpdr
    fsgsksgtsavlaitglqsedeadyycqsrdisqyvfgggtkltvlrtvaapsvfifpps
    deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
    skadyekhkvyacevthqglsspvtksfnrg