PDB entry 3nox

View 3nox on RCSB PDB site
Description: Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone
Class: hydrolase
Keywords: exopeptidase, alpha/beta hydrolase fold, beta barrel, beta propeller, dpp4, dimer, protein:inhibitor complex, aminopeptidase, glycoprotein, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, hydrolase
Deposited on 2010-06-25, released 2010-08-11
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 2.34 Å
R-factor: 0.198
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, hCG_39008
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3noxa1, d3noxa2
  • Chain 'B':
    Compound: Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, hCG_39008
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3noxb1, d3noxb2
  • Heterogens: NAG, 6A5, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3noxA (A:)
efsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfd
efghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvt
wspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalww
spngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsl
ssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgr
wnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctf
itkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqy
ysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldf
iilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiva
sfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvt
smvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfk
qveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythms
hfikqcfslppleqkliseedlnsavdhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3noxA (A:)
rktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdefg
hsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwsp
vghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssv
tnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnc
lvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitk
gtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysv
sfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiil
netkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmv
lgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfi
kqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3noxB (B:)
efsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfd
efghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvt
wspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalww
spngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsl
ssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgr
wnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctf
itkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqy
ysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldf
iilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiva
sfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvt
smvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfk
qveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythms
hfikqcfslppleqkliseedlnsavdhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3noxB (B:)
rktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfdefg
hsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwsp
vghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspn
gtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssv
tnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnc
lvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitk
gtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysv
sfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiil
netkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfd
grgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmv
lgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqve
yllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfi
kqcfslp