PDB entry 3nkx

View 3nkx on RCSB PDB site
Description: Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
Class: protein binding, signaling protein
Keywords: protein binding, signaling protein
Deposited on 2010-06-21, released 2010-09-15
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-02-26, with a file datestamp of 2014-02-21.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.206
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein zeta/delta
    Species: Homo sapiens [TaxId:9606]
    Gene: YWHAZ
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3nkxa_
  • Chain 'B':
    Compound: 14-3-3 protein zeta/delta
    Species: Homo sapiens [TaxId:9606]
    Gene: YWHAZ
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3nkxb_
  • Chain 'P':
    Compound: Peptide of RAF proto-oncogene serine/threonine-protein kinase
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: Peptide of RAF proto-oncogene serine/threonine-protein kinase
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: PPI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3nkxA (A:)
mdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswr
vvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylk
mkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyye
ilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwtsdtqgdeaeag
eggen

    Sequence, based on observed residues (ATOM records): (download) 
    >3nkxA (A:)
dknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswrv
vssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylkm
kgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyyei
lnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3nkxB (B:)
mdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswr
vvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylk
mkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyye
ilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwtsdtqgdeaeag
eggen

    Sequence, based on observed residues (ATOM records): (download) 
    >3nkxB (B:)
mdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswr
vvssieqkteekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylkmk
gdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyyeil
nspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.