PDB entry 3ncf
View 3ncf on RCSB PDB site
Description: A mutant human Prolactin receptor antagonist H30A in complex with the mutant extracellular domain H188A of the human prolactin receptor
Class: hormone/hormone receptor
Keywords: pH dependence, hematopoietic cytokine, HORMONE-HORMONE RECEPTOR complex
Deposited on
2010-06-04, released
2010-09-29
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-08, with a file datestamp of
2017-11-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Prolactin
Species: Homo sapiens [TaxId:9606]
Gene: hPRL, PRL
Database cross-references and differences (RAF-indexed):
- Uniprot P01236 (1-185)
- initiating methionine (0)
- engineered mutation (16)
- engineered mutation (115)
Domains in SCOPe 2.08: d3ncfa_ - Chain 'B':
Compound: Prolactin receptor
Species: Homo sapiens [TaxId:9606]
Gene: hPRLr, PRLR
Database cross-references and differences (RAF-indexed):
- Uniprot P16471 (1-End)
- initiating methionine (0)
- engineered mutation (187)
Domains in SCOPe 2.08: d3ncfb1, d3ncfb2 - Heterogens: NA, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>3ncfA (A:)
mlrdlfdravvlshyianlssemfsefdkrythgrgfitkainschtsslatpedkeqaq
qmnqkdflslivsilrswneplyhlvtevrgmqeapeailskaveieeqtkrllermeli
vsqvhpetkeneiypvwsglpslqmadeesrlsayynllhclrrdshkidnylkllkcri
ihnnnc
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3ncfB (B:)
mlppgkpeifkcrspnketftcwwrpgtdgglptnysltyhregetlmhecpdyitggpn
schfgkqytsmwrtyimmvnatnqmgssfsdelyvdvtyivqpdpplelavevkqpedrk
pylwikwspptlidlktgwftllyeirlkpekaaeweihfagqqtefkilslhpgqkylv
qvrckpdagywsawspatfiqipsdftmnd
Sequence, based on observed residues (ATOM records): (download)
>3ncfB (B:)
mlppgkpeifkcrspnketftcwwrpgtdgglptnysltyhregetlmhecpdyitggpn
schfgkqytsmwrtyimmvnatnqmgssfsdelyvdvtyivqpdpplelavevkqpedrk
pylwikwspptlidlktgwftllyeirlkpekaaeweihfagqqtefkilslhpgqkylv
qvrckpdagywsawspatfiqipsdf