PDB entry 3n8y

View 3n8y on RCSB PDB site
Description: Structure of Aspirin Acetylated Cyclooxygenase-1 in Complex with Diclofenac
Class: oxidoreductase
Keywords: cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, aspirin acetylation, diclofenac, merohedral twinned, OXIDOREDUCTASE
Deposited on 2010-05-28, released 2010-07-28
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-09-18, with a file datestamp of 2013-09-13.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.184
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Prostaglandin G/H synthase 1
    Species: Ovis aries [TaxId:9940]
    Gene: COX1, PTGS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05979 (0-552)
      • conflict (60)
    Domains in SCOPe 2.04: d3n8ya1, d3n8ya2
  • Chain 'B':
    Compound: Prostaglandin G/H synthase 1
    Species: Ovis aries [TaxId:9940]
    Gene: COX1, PTGS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05979 (0-552)
      • conflict (60)
      • microheterogeneity (498)
    Domains in SCOPe 2.04: d3n8yb1, d3n8yb2
  • Heterogens: HEM, DIF, BOG, SAL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3n8yA (A:)
pvnpccyypcqhqgicvrfgldryqcdctrtgysgpnctipeiwtwlrttlrpspsfihf
llthgrwlwdfvnatfirdtlmrlvltvrsnlipspptyniahdyiswesfsnvsyytri
lpsvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqgtnlmfaffaqhfthqffk
tsgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklkyqmlngevyppsveeapv
lmhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvcdllkaehptwgdeqlfqt
arliligetikivieeyvqqlsgyflqlkfdpellfgaqfqyrnriamefnqlyhwhplm
pdsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagrigggrnidhhilhvavdv
ikesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaeleelygdidalefypglllek
chpnsifgesmiemgapfslkgllgnpicspeywkastfggevgfnlvktatlkklvcln
tktcpyvsfhvpd

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3n8yB (B:)
pvnpccyypcqhqgicvrfgldryqcdctrtgysgpnctipeiwtwlrttlrpspsfihf
llthgrwlwdfvnatfirdtlmrlvltvrsnlipspptyniahdyiswesfsnvsyytri
lpsvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqgtnlmfaffaqhfthqffk
tsgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklkyqmlngevyppsveeapv
lmhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvcdllkaehptwgdeqlfqt
arliligetikivieeyvqqlsgyflqlkfdpellfgaqfqyrnriamefnqlyhwhplm
pdsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagrigggrnidhhilhvavdv
ikesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaeleelygdidalefypglllek
chpnsifgesmiemgapfslkgllgnpicspeywkastfggevgfnlvktatlkklvcln
tktcpyvsfhvpd