PDB entry 3n8w

View 3n8w on RCSB PDB site
Description: Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen
Class: oxidoreductase
Keywords: cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, flurbiprofen, merohedral twinned, heterodimer mutant, OXIDOREDUCTASE
Deposited on 2010-05-28, released 2010-07-28
The last revision prior to the SCOPe 2.03 freeze date was dated 2010-09-01, with a file datestamp of 2010-08-27.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.179
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Prostaglandin G/H synthase 1
    Species: Ovis aries [TaxId:9940]
    Gene: COX1, PTGS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05979 (0-552)
      • conflict (60)
    Domains in SCOPe 2.03: d3n8wa1, d3n8wa2
  • Chain 'B':
    Compound: Prostaglandin G/H synthase 1
    Species: Ovis aries [TaxId:9940]
    Gene: PTGS1, COX1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05979 (0-552)
      • conflict (60)
      • conflict (88)
  • Heterogens: HEM, FLP, BOG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3n8wA (A:)
pvnpccyypcqhqgicvrfgldryqcdctrtgysgpnctipeiwtwlrttlrpspsfihf
llthgrwlwdfvnatfirdtlmrlvltvrsnlipspptyniahdyiswesfsnvsyytri
lpsvprdcptpmgtkgkkqlpdaeflsrrfllrrkfipdpqgtnlmfaffaqhfthqffk
tsgkmgpgftkalghgvdlghiygdnlerqyqlrlfkdgklkyqmlngevyppsveeapv
lmhyprgippqsqmavgqevfgllpglmlyatiwlrehnrvcdllkaehptwgdeqlfqt
arliligetikivieeyvqqlsgyflqlkfdpellfgaqfqyrnriamefnqlyhwhplm
pdsfrvgpqdysyeqflfntsmlvdygvealvdafsrqpagrigggrnidhhilhvavdv
ikesrvlrlqpfneyrkrfgmkpytsfqeltgekemaaeleelygdidalefypglllek
chpnsifgesmiemgapfslkgllgnpicspeywkastfggevgfnlvktatlkklvcln
tktcpyvsfhvpd

  • Chain 'B':
    No sequence available.