PDB entry 3n84

View 3n84 on RCSB PDB site
Description: Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP
Class: protein binding/peptide
Keywords: ligand preorganization, macrocycles, macrocyclic ligands, Golgi apparatus, Host-virus interaction, Phosphoprotein, protein binding-peptide complex
Deposited on 2010-05-27, released 2011-01-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-01-12, with a file datestamp of 2011-01-07.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.18
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth factor receptor-bound protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GRB2, ASH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3n84a_
  • Chain 'B':
    Compound: Growth factor receptor-bound protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GRB2, ASH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3n84b_
  • Chain 'C':
    Compound: Growth factor receptor-bound protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GRB2, ASH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3n84c_
  • Chain 'D':
    Compound: Growth factor receptor-bound protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GRB2, ASH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3n84d_
  • Chain 'E':
    Compound: Growth factor receptor-bound protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GRB2, ASH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62993 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.07: d3n84e1, d3n84e2
  • Chain 'F':
    Compound: Growth factor receptor-bound protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GRB2, ASH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3n84f_
  • Chain 'G':
    Compound: 23-membered peptide-like macrocyclic ligand
    Database cross-references and differences (RAF-indexed):
    • PDB 3N84 (0-5)
  • Chain 'H':
    Compound: 23-membered peptide-like macrocyclic ligand
    Database cross-references and differences (RAF-indexed):
    • PDB 3N84 (0-5)
  • Chain 'I':
    Compound: 23-membered peptide-like macrocyclic ligand
    Database cross-references and differences (RAF-indexed):
    • PDB 3N84 (0-5)
  • Chain 'J':
    Compound: 23-membered peptide-like macrocyclic ligand
    Database cross-references and differences (RAF-indexed):
    • PDB 3N84 (0-5)
  • Chain 'K':
    Compound: 23-membered peptide-like macrocyclic ligand
    Database cross-references and differences (RAF-indexed):
    • PDB 3N84 (0-5)
  • Chain 'L':
    Compound: 23-membered peptide-like macrocyclic ligand
    Database cross-references and differences (RAF-indexed):
    • PDB 3N84 (0-5)
  • Heterogens: CL, GOL, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3n84A (A:)
miemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvl
rdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

    Sequence, based on observed residues (ATOM records): (download) 
    >3n84A (A:)
mkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdg
agkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3n84B (B:)
miemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvl
rdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

    Sequence, based on observed residues (ATOM records): (download) 
    >3n84B (B:)
emkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrd
gagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqpt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3n84C (C:)
miemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvl
rdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

    Sequence, based on observed residues (ATOM records): (download) 
    >3n84C (C:)
mkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdg
agkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3n84D (D:)
miemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvl
rdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

    Sequence, based on observed residues (ATOM records): (download) 
    >3n84D (D:)
emkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrd
gagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqv

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3n84E (E:)
miemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvl
rdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

    Sequence, based on observed residues (ATOM records): (download) 
    >3n84E (E:)
miemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvl
rdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3n84F (F:)
miemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvl
rdgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqa

    Sequence, based on observed residues (ATOM records): (download) 
    >3n84F (F:)
iemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlr
dgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieq

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.