PDB entry 3n7p

View 3n7p on RCSB PDB site
Description: crystal structure of the ectodomain complex of the cgrp receptor, a class-b gpcr, reveals the site of drug antagonism
Deposited on 2010-05-27, released 2010-09-15
The last revision was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Calcitonin gene-related peptide type 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CALCRL, CALRL_HUMAN, CGRPR
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Calcitonin gene-related peptide type 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CALCRL, CALRL_HUMAN, CGRPR
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Calcitonin gene-related peptide type 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CALCRL, CALRL_HUMAN, CGRPR
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Receptor activity-modifying protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RAMP1, RAMP1_HUMAN
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Receptor activity-modifying protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RAMP1, RAMP1_HUMAN
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Receptor activity-modifying protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RAMP1, RAMP1_HUMAN
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Calcitonin gene-related peptide type 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CALCRL, CALRL_HUMAN, CGRPR
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: Receptor activity-modifying protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RAMP1, RAMP1_HUMAN
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.07, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3n7pA (A:)
    gshmeleespedsiqlgvtrnkimtaqyecyqkimqdpiqqaegvycnrtwdgwlcwndv
    aagtesmqlcpdyfqdfdpsekvtkicdqdgnwfrhpasnrtwtnytqcnvnthe
    

    Sequence, based on observed residues (ATOM records):
    >3n7pA (A:)
    edsiqlgvtrnkimtaqyecyqkimqdpiqqaegvycnrtwdgwlcwndvaagtesmqlc
    pdyfqdfdpsekvtkicdqdgnwfrhpasnrtwtnytqcn
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3n7pB (B:)
    gshmeleespedsiqlgvtrnkimtaqyecyqkimqdpiqqaegvycnrtwdgwlcwndv
    aagtesmqlcpdyfqdfdpsekvtkicdqdgnwfrhpasnrtwtnytqcnvnthe
    

    Sequence, based on observed residues (ATOM records):
    >3n7pB (B:)
    siqlgvtrnkimtaqyecyqkimqdpiqqaegvycnrtwdgwlcwndvaagtesmqlcpd
    yfqdfdpsekvtkicdqdgnwfrhpasnrtwtnytqcnv
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3n7pC (C:)
    gshmeleespedsiqlgvtrnkimtaqyecyqkimqdpiqqaegvycnrtwdgwlcwndv
    aagtesmqlcpdyfqdfdpsekvtkicdqdgnwfrhpasnrtwtnytqcnvnthe
    

    Sequence, based on observed residues (ATOM records):
    >3n7pC (C:)
    gvtrnkimtaqyecyqkimqdpinrtwdgwlcwgtesmqlcpdyvtkicdqdgnwfrhpa
    snrtwtny
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3n7pD (D:)
    gshmacqeanygallrelcltqfqvdmeavgetlwcdwgrtirsyreladctwhmaeklg
    cfwpnaevdrfflavhgryfrscpisgravrdppgs
    

    Sequence, based on observed residues (ATOM records):
    >3n7pD (D:)
    cqeanygallrelcltqfqvdmeavgetlwcdwgrtirsyreladctwhmaeklgcfwpn
    aevdrfflavhgryfrscpisgravrdppg
    

  • Chain 'E':
    Sequence, based on SEQRES records:
    >3n7pE (E:)
    gshmacqeanygallrelcltqfqvdmeavgetlwcdwgrtirsyreladctwhmaeklg
    cfwpnaevdrfflavhgryfrscpisgravrdppgs
    

    Sequence, based on observed residues (ATOM records):
    >3n7pE (E:)
    cqeanygallrelcltqfqvdmeavgetlwcdwgrtirsyreladctwhmaeklgcfwpn
    aevdrfflavhgryfrscp
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >3n7pF (F:)
    gshmacqeanygallrelcltqfqvdmeavgetlwcdwgrtirsyreladctwhmaeklg
    cfwpnaevdrfflavhgryfrscpisgravrdppgs
    

    Sequence, based on observed residues (ATOM records):
    >3n7pF (F:)
    cqeanygallrelcltqfqvdmeavgetlwcdwgrtirsyreladctwhmaeklgcfwpn
    aevdrfflavhgryfrscp
    

  • Chain 'J':
    Sequence, based on SEQRES records:
    >3n7pJ (J:)
    gshmeleespedsiqlgvtrnkimtaqyecyqkimqdpiqqaegvycnrtwdgwlcwndv
    aagtesmqlcpdyfqdfdpsekvtkicdqdgnwfrhpasnrtwtnytqcnvnthe
    

    Sequence, based on observed residues (ATOM records):
    >3n7pJ (J:)
    iqlgvtrnkimtaqyecyqkimqdpiqqaegvycnrtwdgwlcwndvaagtesmqlcpdy
    fqdfdpsekvtkicdqdgnwfrhpasnrtwtnytqcn
    

  • Chain 'R':
    Sequence, based on SEQRES records:
    >3n7pR (R:)
    gshmacqeanygallrelcltqfqvdmeavgetlwcdwgrtirsyreladctwhmaeklg
    cfwpnaevdrfflavhgryfrscpisgravrdppgs
    

    Sequence, based on observed residues (ATOM records):
    >3n7pR (R:)
    cqeanygallrelcltqfqvdmeavgetlwcdwgrtirsyreladctwhmaeklgcfwpn
    aevdrfflavhgryfrscpisgravrdppgs