PDB entry 3n5h

View 3n5h on RCSB PDB site
Description: Human fpps complex with NOV_304
Class: transferase/transferase inhibitor
Keywords: BISPHOSPHONATE; FRAGMENT-BASED SCREENING; TRANSFERASE; ISOPRENE BIOSYNTHESIS; CHOLESTEROL BIOSYNTHESIS, RANSFERASE-TRANSFERASE INHIBITOR complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-05-25, released 2010-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'F':
    Compound: farnesyl pyrophosphate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3n5hf_
  • Heterogens: GO0, PO4, HOH

PDB Chain Sequences:

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3n5hF (F:)
gpnsdvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrglt
vvvafrelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpg
vgldaindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnv
dlvrftekryksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqd
dyldlfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvka
lyeeldlpavflqyeedsyshimalieqyaaplppavflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >3n5hF (F:)
dvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvva
frelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgld
aindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvr
ftekryksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyld
lfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyee
ldlpavflqyeedsyshimalieqyaaplppavflglarkiyk