PDB entry 3mzs

View 3mzs on RCSB PDB site
Description: Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol
Class: oxidoreductase
Keywords: CYP11A1, CYTOCHROME P450, MONOOXYGENASE, SIDE CHAIN CLEAVAGE ENZYME, CHOLESTEROL, Cholesterol 20-22-desmolase, STEROID METABOLISM, OXIDOREDUCTASE, HEME
Deposited on 2010-05-12, released 2010-12-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-03-02, with a file datestamp of 2011-02-25.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.266
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cholesterol side-chain cleavage enzyme
    Species: Bos taurus [TaxId:9913]
    Gene: CYP11A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3mzsa_
  • Chain 'B':
    Compound: Cholesterol side-chain cleavage enzyme
    Species: Bos taurus [TaxId:9913]
    Gene: CYP11A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3mzsb_
  • Chain 'C':
    Compound: Cholesterol side-chain cleavage enzyme
    Species: Bos taurus [TaxId:9913]
    Gene: CYP11A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3mzsc_
  • Chain 'D':
    Compound: Cholesterol side-chain cleavage enzyme
    Species: Bos taurus [TaxId:9913]
    Gene: CYP11A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3mzsd_
  • Heterogens: HEM, HC9, IPA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mzsA (A:)
mastktprpyseipspgdngwlnlyhfwrekgsqrihfrhienfqkygpiyreklgnles
vyiihpedvahlfkfegsyperydippwlayhryyqkpigvlfkksgtwkkdrvvlntev
mapeaiknfipllnpvsqdfvsllhkrikqqgsgkfvgdikedlfhfafesitnvmfger
lgmleetvnpeaqkfidavykmfhtsvpllnvppelyrlfrtktwrdhvaawdtifnkae
kyteifyqdlrrktefrnypgilycllksekmlledvkanitemlaggvnttsmtlqwhl
yemarslnvqemlreevlnarrqaegdiskmlqmvpllkasiketlrlhpisvtlqrype
sdlvlqdylipaktlvqvaiyamgrdpaffsspdkfdptrwlskdkdlihfrnlgfgwgv
rqcvgrriaelemtlflihilenfkvemqhigdvdtifnliltpdkpiflvfrpfnqdpp
qahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3mzsA (A:)
tprpyseipspgdngwlnlyhfwrekgsqrihfrhienfqkygpiyreklgnlesvyiih
pedvahlfkfegsyperydippwlayhryyqkpigvlfkksgtwkkdrvvlntevmapea
iknfipllnpvsqdfvsllhkrikqqgsgkfvgdikedlfhfafesitnvmfgerlgmle
etvnpeaqkfidavykmfhtsvpllnvppelyrlfrtktwrdhvaawdtifnkaekytei
fyqdlrrktefrnypgilycllksekmlledvkanitemlaggvnttsmtlqwhlyemar
slnvqemlreevlnarrqaegdiskmlqmvpllkasiketlrlhpisvtlqrypesdlvl
qdylipaktlvqvaiyamgrdpaffsspdkfdptrwlskdkdlihfrnlgfgwgvrqcvg
rriaelemtlflihilenfkvemqhigdvdtifnliltpdkpiflvfrpf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3mzsB (B:)
mastktprpyseipspgdngwlnlyhfwrekgsqrihfrhienfqkygpiyreklgnles
vyiihpedvahlfkfegsyperydippwlayhryyqkpigvlfkksgtwkkdrvvlntev
mapeaiknfipllnpvsqdfvsllhkrikqqgsgkfvgdikedlfhfafesitnvmfger
lgmleetvnpeaqkfidavykmfhtsvpllnvppelyrlfrtktwrdhvaawdtifnkae
kyteifyqdlrrktefrnypgilycllksekmlledvkanitemlaggvnttsmtlqwhl
yemarslnvqemlreevlnarrqaegdiskmlqmvpllkasiketlrlhpisvtlqrype
sdlvlqdylipaktlvqvaiyamgrdpaffsspdkfdptrwlskdkdlihfrnlgfgwgv
rqcvgrriaelemtlflihilenfkvemqhigdvdtifnliltpdkpiflvfrpfnqdpp
qahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3mzsB (B:)
tprpyseipspgdngwlnlyhfwrekgsqrihfrhienfqkygpiyreklgnlesvyiih
pedvahlfkfegsyperydippwlayhryyqkpigvlfkksgtwkkdrvvlntevmapea
iknfipllnpvsqdfvsllhkrikqqgsgkfvgdikedlfhfafesitnvmfgerlgmle
etvnpeaqkfidavykmfhtsvpllnvppelyrlfrtktwrdhvaawdtifnkaekytei
fyqdlrrktefrnypgilycllksekmlledvkanitemlaggvnttsmtlqwhlyemar
slnvqemlreevlnarrqaegdiskmlqmvpllkasiketlrlhpisvtlqrypesdlvl
qdylipaktlvqvaiyamgrdpaffsspdkfdptrwlskdkdlihfrnlgfgwgvrqcvg
rriaelemtlflihilenfkvemqhigdvdtifnliltpdkpiflvfrpf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3mzsC (C:)
mastktprpyseipspgdngwlnlyhfwrekgsqrihfrhienfqkygpiyreklgnles
vyiihpedvahlfkfegsyperydippwlayhryyqkpigvlfkksgtwkkdrvvlntev
mapeaiknfipllnpvsqdfvsllhkrikqqgsgkfvgdikedlfhfafesitnvmfger
lgmleetvnpeaqkfidavykmfhtsvpllnvppelyrlfrtktwrdhvaawdtifnkae
kyteifyqdlrrktefrnypgilycllksekmlledvkanitemlaggvnttsmtlqwhl
yemarslnvqemlreevlnarrqaegdiskmlqmvpllkasiketlrlhpisvtlqrype
sdlvlqdylipaktlvqvaiyamgrdpaffsspdkfdptrwlskdkdlihfrnlgfgwgv
rqcvgrriaelemtlflihilenfkvemqhigdvdtifnliltpdkpiflvfrpfnqdpp
qahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3mzsC (C:)
tprpyseipspgdngwlnlyhfwrekgsqrihfrhienfqkygpiyreklgnlesvyiih
pedvahlfkfegsyperydippwlayhryyqkpigvlfkksgtwkkdrvvlntevmapea
iknfipllnpvsqdfvsllhkrikqqgsgkfvgdikedlfhfafesitnvmfgerlgmle
etvnpeaqkfidavykmfhtsvpllnvppelyrlfrtktwrdhvaawdtifnkaekytei
fyqdlrrktefrnypgilycllksekmlledvkanitemlaggvnttsmtlqwhlyemar
slnvqemlreevlnarrqaegdiskmlqmvpllkasiketlrlhpisvtlqrypesdlvl
qdylipaktlvqvaiyamgrdpaffsspdkfdptrwlskdkdlihfrnlgfgwgvrqcvg
rriaelemtlflihilenfkvemqhigdvdtifnliltpdkpiflvfrpf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3mzsD (D:)
mastktprpyseipspgdngwlnlyhfwrekgsqrihfrhienfqkygpiyreklgnles
vyiihpedvahlfkfegsyperydippwlayhryyqkpigvlfkksgtwkkdrvvlntev
mapeaiknfipllnpvsqdfvsllhkrikqqgsgkfvgdikedlfhfafesitnvmfger
lgmleetvnpeaqkfidavykmfhtsvpllnvppelyrlfrtktwrdhvaawdtifnkae
kyteifyqdlrrktefrnypgilycllksekmlledvkanitemlaggvnttsmtlqwhl
yemarslnvqemlreevlnarrqaegdiskmlqmvpllkasiketlrlhpisvtlqrype
sdlvlqdylipaktlvqvaiyamgrdpaffsspdkfdptrwlskdkdlihfrnlgfgwgv
rqcvgrriaelemtlflihilenfkvemqhigdvdtifnliltpdkpiflvfrpfnqdpp
qahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3mzsD (D:)
tprpyseipspgdngwlnlyhfwrekgsqrihfrhienfqkygpiyreklgnlesvyiih
pedvahlfkfegsyperydippwlayhryyqkpigvlfkksgtwkkdrvvlntevmapea
iknfipllnpvsqdfvsllhkrikqqgsgkfvgdikedlfhfafesitnvmfgerlgmle
etvnpeaqkfidavykmfhtsvpllnvppelyrlfrtktwrdhvaawdtifnkaekytei
fyqdlrrktefrnypgilycllksekmlledvkanitemlaggvnttsmtlqwhlyemar
slnvqemlreevlnarrqaegdiskmlqmvpllkasiketlrlhpisvtlqrypesdlvl
qdylipaktlvqvaiyamgrdpaffsspdkfdptrwlskdkdlihfrnlgfgwgvrqcvg
rriaelemtlflihilenfkvemqhigdvdtifnliltpdkpiflvfrpf