PDB entry 3mvh

View 3mvh on RCSB PDB site
Description: Crystal structure of Akt-1-inhibitor complexes
Class: transferase
Keywords: kinase inhibitor, TRANSFERASE
Deposited on 2010-05-04, released 2010-06-02
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.01 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: v-akt murine thymoma viral oncogene homolog 1 (AKT1)
    Species: Homo sapiens [TaxId:9606]
    Gene: AKT-1, AKT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot B2RAM5
      • engineered (334)
    Domains in SCOPe 2.07: d3mvha_
  • Chain 'B':
    Compound: GSK3-beta peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3MVH (0-9)
  • Heterogens: MN, WFE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3mvhA (A:)
    gamdprvtmnefeylkllgkgtfgkvilvkekatgryyamkilkkevivakdevahtlte
    nrvlqnsrhpfltalkysfqthdrlcfvmeyanggelffhlsrervfsedrarfygaeiv
    saldylhseknvvyrdlklenlmldkdghikitdfglckegikdgatmktfcgtpeylap
    evledndygravdwwglgvvmyemmcgrlpfynqdheklfelilmeeirfprtlgpeaks
    llsgllkkdpkqrlgggsedakeimqhrffagivwqhvyekklsppfkpqvtsetdtryf
    deeftaqmititppdqddsmecvdserrphfpqfdysassta
    

    Sequence, based on observed residues (ATOM records): (download)
    >3mvhA (A:)
    vtmnefeylkllgkgtfgkvilvkekatgryyamkilkkevivakdevahtltenrvlqn
    srhpfltalkysfqthdrlcfvmeyanggelffhlsrervfsedrarfygaeivsaldyl
    hseknvvyrdlklenlmldkdghikitdfglckegikdgatmktfcgtpeylapevledn
    dygravdwwglgvvmyemmcgrlpfynqdheklfelilmeeirfprtlgpeaksllsgll
    kkdpkqrlgggsedakeimqhrffagivwqhvyekklsppfkpqvtsetdtryfdeefta
    qrphfpqfdysa
    

  • Chain 'B':
    No sequence available.