PDB entry 3mu6

View 3mu6 on RCSB PDB site
Description: Inhibiting the Binding of Class IIa Histone Deacetylases to Myocyte Enhancer Factor-2 by Small Molecules
Class: DNA binding protein/DNA
Keywords: MADS-box/MEF2 domain, transcription co-factors, protein-DNA complex, protein-protein docking, DNA BINDING PROTEIN-DNA complex
Deposited on 2010-05-01, released 2011-11-02
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.43 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: myocyte-specific enhancer factor 2a
    Species: Homo sapiens [TaxId:9606]
    Gene: MEF2A, MEF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02078 (0-70)
      • engineered mutation (69)
    Domains in SCOPe 2.07: d3mu6a_
  • Chain 'B':
    Compound: myocyte-specific enhancer factor 2a
    Species: Homo sapiens [TaxId:9606]
    Gene: MEF2A, MEF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02078 (0-70)
      • engineered mutation (69)
    Domains in SCOPe 2.07: d3mu6b_
  • Chain 'C':
    Compound: myocyte-specific enhancer factor 2a
    Species: Homo sapiens [TaxId:9606]
    Gene: MEF2A, MEF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02078 (0-70)
      • engineered mutation (69)
    Domains in SCOPe 2.07: d3mu6c_
  • Chain 'D':
    Compound: myocyte-specific enhancer factor 2a
    Species: Homo sapiens [TaxId:9606]
    Gene: MEF2A, MEF2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02078 (0-70)
      • engineered mutation (69)
    Domains in SCOPe 2.07: d3mu6d_
  • Chain 'E':
    Compound: DNA (5'-d(*ap*ap*ap*gp*cp*tp*ap*tp*tp*ap*tp*tp*ap*gp*cp*tp*t)-3')
  • Chain 'F':
    Compound: DNA (5'-d(*tp*ap*ap*gp*cp*tp*ap*ap*tp*ap*ap*tp*ap*gp*cp*tp*t)-3')
  • Chain 'G':
    Compound: DNA (5'-d(*ap*ap*ap*gp*cp*tp*ap*tp*tp*ap*tp*tp*ap*gp*cp*tp*t)-3')
  • Chain 'H':
    Compound: DNA (5'-d(*tp*ap*ap*gp*cp*tp*ap*ap*tp*ap*ap*tp*ap*gp*cp*tp*t)-3')
  • Heterogens: BXL

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3mu6A (A:)
    grkkiqitrimdernrqvtftkrkfglmkkayelsvlcdceialiifnssnklfqyastd
    mdkvllkytay
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3mu6B (B:)
    grkkiqitrimdernrqvtftkrkfglmkkayelsvlcdceialiifnssnklfqyastd
    mdkvllkytay
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3mu6C (C:)
    grkkiqitrimdernrqvtftkrkfglmkkayelsvlcdceialiifnssnklfqyastd
    mdkvllkytay
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3mu6D (D:)
    grkkiqitrimdernrqvtftkrkfglmkkayelsvlcdceialiifnssnklfqyastd
    mdkvllkytay
    

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.