PDB entry 3mtn

View 3mtn on RCSB PDB site
Description: Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor
Class: hydrolase
Keywords: ubiquitin-specific protease activity, hydrolase, ubiquitin biology, structural genomics consortium, sgc, activator, alternative splicing, chromatin regulator, nucleus, polymorphism, protease, thiol protease, transcription, transcription regulation, ubl conjugation pathway, cytoplasm, isopeptide bond, phosphoprotein, ubl conjugation, inhibitor
Deposited on 2010-04-30, released 2010-06-09
The last revision prior to the SCOPe 2.02 freeze date was dated 2010-06-09, with a file datestamp of 2010-06-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.22
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin carboxyl-terminal hydrolase 21
    Species: Homo sapiens [TaxId:9606]
    Gene: PP1490, USP21, USP23
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3mtna_
  • Chain 'B':
    Compound: ubiquitin variant ubv.21.4
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS27A, UBA52, UBA80, UBB, UBC, UBCEP1, UBCEP2, UBQ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62988 (3-78)
      • expression tag (2)
      • engineered mutation (66)
      • engineered mutation (70)
      • engineered mutation (72)
    Domains in SCOPe 2.02: d3mtnb_
  • Chain 'C':
    Compound: Ubiquitin carboxyl-terminal hydrolase 21
    Species: Homo sapiens [TaxId:9606]
    Gene: PP1490, USP21, USP23
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3mtnc_
  • Chain 'D':
    Compound: ubiquitin variant ubv.21.4
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS27A, UBA52, UBA80, UBB, UBC, UBCEP1, UBCEP2, UBQ
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62988 (3-78)
      • expression tag (2)
      • engineered mutation (66)
      • engineered mutation (70)
      • engineered mutation (72)
    Domains in SCOPe 2.02: d3mtnd_
  • Heterogens: ZN, CL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mtnA (A:)
mgsshhhhhhssglvprgssghvglrnlgntcflnavlqclsstrplrdfclrrdfrqev
pgggraqelteafadvigalwhpdsceavnptrfravfqkyvpsfsgysqqdaqeflkll
merlhleinrrgrrappilangpvpspprrggalleepelsdddranlmwkryleredsk
ivdlfvgqlksclkcqacgyrsttfevfcdlslpipkkgfaggkvslrdcfnlftkeeel
esenapvcdrcrqktrstkkltvqrfprilvlhlnrfsasrgsikkssvgvdfplqrlsl
gdfasdkagspvyqlyalcnhsgsvhyghytalcrcqtgwhvyndsrvspvsenqvasse
gyvlfyqlmqepp

    Sequence, based on observed residues (ATOM records): (download) 
    >3mtnA (A:)
ghvglrnlgntcflnavlqclsstrplrdfclrrdfrqevpgggraqelteafadvigal
whpdsceavnptrfravfqkyvpsfsgysqqdaqeflkllmerlhleinrrlsdddranl
mwkryleredskivdlfvgqlksclkcqacgyrsttfevfcdlslpipkkgfaggkvslr
dcfnlftkeeelesenapvcdrcrqktrstkkltvqrfprilvlhlnrfsargsikkssv
gvdfplqrlslgdfasspvyqlyalcnhsgsvhyghytalcrcqtgwhvyndsrvspvse
nqvassegyvlfyqlm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3mtnB (B:)
gshmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtls
dyniqkwstlflllrlrggggggsg

    Sequence, based on observed residues (ATOM records): (download) 
    >3mtnB (B:)
hmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdy
niqkwstlflllrlrgg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3mtnC (C:)
mgsshhhhhhssglvprgssghvglrnlgntcflnavlqclsstrplrdfclrrdfrqev
pgggraqelteafadvigalwhpdsceavnptrfravfqkyvpsfsgysqqdaqeflkll
merlhleinrrgrrappilangpvpspprrggalleepelsdddranlmwkryleredsk
ivdlfvgqlksclkcqacgyrsttfevfcdlslpipkkgfaggkvslrdcfnlftkeeel
esenapvcdrcrqktrstkkltvqrfprilvlhlnrfsasrgsikkssvgvdfplqrlsl
gdfasdkagspvyqlyalcnhsgsvhyghytalcrcqtgwhvyndsrvspvsenqvasse
gyvlfyqlmqepp

    Sequence, based on observed residues (ATOM records): (download) 
    >3mtnC (C:)
ghvglrnlgntcflnavlqclsstrplrdfclrrdfrqevpgggraqelteafadvigal
whpdsceavnptrfravfqkyvpsfsgysqqdaqeflkllmerlhleinrrsdddranlm
wkryleredskivdlfvgqlksclkcqacgyrsttfevfcdlslpipkkgfgkvslrdcf
nlftkeeelesenapvcdrcrqktrstkkltvqrfprilvlhlnrfsasrgsikkssvgv
dfplqrlslgdfasspvyqlyalcnhsgsvhyghytalcrcqtgwhvyndsrvspvsenq
vassegyvlfyqlm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3mtnD (D:)
gshmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtls
dyniqkwstlflllrlrggggggsg

    Sequence, based on observed residues (ATOM records): (download) 
    >3mtnD (D:)
hmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdy
niqkwstlflllrlrgg