PDB entry 3mpe

View 3mpe on RCSB PDB site
Description: Crystal structure of human Cathepsin-S C25S mutant with bound drug
Class: hydrolase
Keywords: CatS, Cathepsin S, Diazinones, Pyrazole, P3, HYDROLASE
Deposited on 2010-04-26, released 2010-06-30
Made obsolete by 5qby on 2017-12-20

The last revision prior to the SCOPe 2.07 freeze date was dated 2017-12-20, with a file datestamp of 2017-12-15.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cathepsin S
    Species: Homo sapiens [TaxId:9606]
    Gene: CTSS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25774 (0-217)
      • engineered (25)
    Domains in SCOPe 2.07: d3mpea_
  • Chain 'B':
    Compound: cathepsin S
    Species: Homo sapiens [TaxId:9606]
    Gene: CTSS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25774 (Start-217)
      • engineered (25)
    Domains in SCOPe 2.07: d3mpeb_
  • Heterogens: N2A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mpeA (A:)
ilpdsvdwrekgcvtevkyqgscgaswafsavgaleaqlklktgklvslsaqnlvdcste
kygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpyg
redvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkey
wlvknswghnfgeegyirmarnkgnhcgiasfpsypeila

    Sequence, based on observed residues (ATOM records): (download) 
    >3mpeA (A:)
ilpdsvdwrekgcvtevkyqgscgaswafsavgaleaqlklktgklvslsaqnlvdcste
kygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpyg
redvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkey
wlvknswghnfgeegyirmarnkgnhcgiasfpsypei

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3mpeB (B:)
ilpdsvdwrekgcvtevkyqgscgaswafsavgaleaqlklktgklvslsaqnlvdcste
kygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpyg
redvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkey
wlvknswghnfgeegyirmarnkgnhcgiasfpsypeila

    Sequence, based on observed residues (ATOM records): (download) 
    >3mpeB (B:)
lpdsvdwrekgcvtevkyqgscgaswafsavgaleaqlklktgklvslsaqnlvdcstek
ygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpygr
edvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkeyw
lvknswghnfgeegyirmarnkgnhcgiasfpsypei