PDB entry 3mp4

View 3mp4 on RCSB PDB site
Description: crystal structure of human lyase r41m mutant
Deposited on 2010-04-24, released 2010-06-16
The last revision was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hydroxymethylglutaryl-CoA lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35914 (0-End)
      • engineered (13)
  • Chain 'B':
    Compound: hydroxymethylglutaryl-CoA lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35914 (0-End)
      • engineered (13)
  • Chain 'C':
    Compound: hydroxymethylglutaryl-CoA lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35914 (0-End)
      • engineered (13)
  • Chain 'D':
    Compound: hydroxymethylglutaryl-CoA lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35914 (0-End)
      • engineered (13)
  • Chain 'E':
    Compound: hydroxymethylglutaryl-CoA lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35914 (0-End)
      • engineered (13)
  • Chain 'F':
    Compound: hydroxymethylglutaryl-CoA lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35914 (0-End)
      • engineered (13)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.07, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3mp4A (A:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatckl
    

    Sequence, based on observed residues (ATOM records):
    >3mp4A (A:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatc
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3mp4B (B:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatckl
    

    Sequence, based on observed residues (ATOM records):
    >3mp4B (B:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatc
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3mp4C (C:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatckl
    

    Sequence, based on observed residues (ATOM records):
    >3mp4C (C:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatc
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3mp4D (D:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatckl
    

    Sequence, based on observed residues (ATOM records):
    >3mp4D (D:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatc
    

  • Chain 'E':
    Sequence, based on SEQRES records:
    >3mp4E (E:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatckl
    

    Sequence, based on observed residues (ATOM records):
    >3mp4E (E:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatc
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >3mp4F (F:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkknincsieesf
    qrfdailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtig
    vgtpgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggcp
    yaqgasgnlatedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatckl
    

    Sequence, based on observed residues (ATOM records):
    >3mp4F (F:)
    tlpkrvkivevgpmdglqneknivstpvkiklidmlseaglsviettsfvspkwvpqmgd
    htevlkgiqkfpginypvltpnlkgfeaavaagakevvifgaaselftkkcsieesfqrf
    dailkaaqsanisvrgyvscalgcpyegkispakvaevtkkfysmgcyeislgdtigvgt
    pgimkdmlsavmqevplaalavhchdtygqalantlmalqmgvsvvdssvaglggasgnl
    atedlvymleglgihtgvnlqklleagnficqalnrktsskvaqatc