PDB entry 3mlx

View 3mlx on RCSB PDB site
Description: Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with an MN V3 peptide
Class: immune system
Keywords: human monoclonal antibody, Fab, HIV-1, gp120, third variable loop, antibody-antigen interaction, IMMUNE SYSTEM
Deposited on 2010-04-18, released 2010-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Human monoclonal anti-HIV-1 gp120 V3 antibody 3074 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3MLX (0-227)
    Domains in SCOPe 2.08: d3mlxh1, d3mlxh2
  • Chain 'I':
    Compound: Human monoclonal anti-HIV-1 gp120 V3 antibody 3074 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3MLX (0-227)
    Domains in SCOPe 2.08: d3mlxi1, d3mlxi2
  • Chain 'L':
    Compound: Human monoclonal anti-HIV-1 gp120 V3 antibody 3074 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3MLX (0-210)
    Domains in SCOPe 2.08: d3mlxl1, d3mlxl2
  • Chain 'M':
    Compound: Human monoclonal anti-HIV-1 gp120 V3 antibody 3074 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3MLX (0-210)
    Domains in SCOPe 2.08: d3mlxm1, d3mlxm2
  • Chain 'P':
    Compound: HIV-1 gp120 third variable region (V3) crown
    Species: HIV-1 M:B_MN [TaxId:11696]
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: HIV-1 gp120 third variable region (V3) crown
    Species: HIV-1 M:B_MN [TaxId:11696]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3mlxH (H:)
qvqlqesgpglvkpsetlsltctvsggsisgfhwswirqppgkgleyigyiyysgstsyn
pslksrvsmsvdtsrnqfslelssvtaadtavyycardfgeyhydgrgfqcegfdlwgqg
tlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3mlxI (I:)
qvqlqesgpglvkpsetlsltctvsggsisgfhwswirqppgkgleyigyiyysgstsyn
pslksrvsmsvdtsrnqfslelssvtaadtavyycardfgeyhydgrgfqcegfdlwgqg
tlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtf
pavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3mlxL (L:)
svltqppsvsaapgqkvtiscsgsssnignnmvswyqqhpgtapklliyenskrpsgipd
rfsgsrsgtsatlgiiglqtgdeaeyycatwdgslrtvfgggtkltvlsqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvragvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvapt

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3mlxM (M:)
svltqppsvsaapgqkvtiscsgsssnignnmvswyqqhpgtapklliyenskrpsgipd
rfsgsrsgtsatlgiiglqtgdeaeyycatwdgslrtvfgggtkltvlsqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvragvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvapt

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.