SCOPe 2.08: Structural Classification of Proteins

PDB entry 3mfe

View 3mfe on RCSB PDB site
Description: Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant with H0 movement
Class: hydrolase
Keywords: Catalytic Domain, Hydrogen Bonding, Mycobacterium tuberculosis, Oxazolidinones, Protease Inhibitors, Proteasome Endopeptidase Complex, Protein Carbonylation, Protein Conformation, Protein Subunits, Substrate Specificity, Thiazoles, helix movement, HYDROLASE
Deposited on 2010-04-02, released 2010-06-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-06-23, with a file datestamp of 2010-06-18.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.224
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

Chain '1':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
Domains in SCOPe 2.08: d3mfe1_
Chain '2':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfe2_
Chain 'A':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
  - initiating methionine (0)
Domains in SCOPe 2.08: d3mfea_
Chain 'B':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
  - initiating methionine (0)
Domains in SCOPe 2.08: d3mfeb_
Chain 'C':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfec_
Chain 'D':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
Domains in SCOPe 2.08: d3mfed_
Chain 'E':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfee_
Chain 'F':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.08: d3mfef_
Chain 'G':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (0-End)
Domains in SCOPe 2.08: d3mfeg_
Chain 'H':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfeh_
Chain 'I':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
  - initiating methionine (0)
Domains in SCOPe 2.08: d3mfei_
Chain 'J':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfej_
Chain 'K':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
Domains in SCOPe 2.08: d3mfek_
Chain 'L':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfel_
Chain 'M':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.08: d3mfem_
Chain 'N':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfen_
Chain 'O':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
Domains in SCOPe 2.08: d3mfeo_
Chain 'P':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfep_
Chain 'Q':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
Domains in SCOPe 2.08: d3mfeq_
Chain 'R':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfer_
Chain 'S':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
  - initiating methionine (0)
Domains in SCOPe 2.08: d3mfes_
Chain 'T':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfet_
Chain 'U':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
Domains in SCOPe 2.08: d3mfeu_
Chain 'V':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (0-End)
Domains in SCOPe 2.08: d3mfev_
Chain 'W':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.08: d3mfew_
Chain 'X':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfex_
Chain 'Y':
Compound: Proteasome subunit alpha
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2169, prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244 (1-End)
Domains in SCOPe 2.08: d3mfey_
Chain 'Z':
Compound: Proteasome subunit beta
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - amidation (0)
Domains in SCOPe 2.08: d3mfez_
Heterogens: HOH

PDB Chain Sequences:

Chain '1':
Sequence, based on SEQRES records: (download)

>3mfe1 (1:)
meqamrerselarkgiaraksvvalayaggvlfvaenpsrslqkiselydrvgfaaagkf
nefdnlrrggiqfadtrgyaydrrdvtgrqlanvyaqtlgtifteqakpyevelcvaeva
hygetkrpelyritydgsiadephfvvmggttepianalkesyaenasltdalriavaal
ragsadtsggdqptlgvaslevavldanrprrafrritgsalqallvdqespqsdgessg