PDB entry 3mbl
View 3mbl on RCSB PDB site
Description: Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP
Class: transferase
Keywords: Kinase inhibitor, Transferase
Deposited on
2010-03-25, released
2010-07-28
The last revision prior to the SCOPe 2.05 freeze date was dated
2010-07-28, with a file datestamp of
2010-07-23.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.169
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Dual specificity mitogen-activated protein kinase kinase 1
Species: Homo sapiens [TaxId:9606]
Gene: MAP2K1, MEK 1, MEK1, PRKMK1
Database cross-references and differences (RAF-indexed):
- Uniprot Q02750 (1-End)
- initiating methionine (0)
Domains in SCOPe 2.05: d3mbla_ - Heterogens: ADP, MG, LSG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3mblA (A:)
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssy
gmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhaf
ikrsdaeevdfagwlcstiglnhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3mblA (A:)
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfpmaifelldyivnepppklpsgvfs
lefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigl