PDB entry 3ma3

View 3ma3 on RCSB PDB site
Description: Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand
Class: transferase
Keywords: ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE, Cell cycle, Cell membrane
Deposited on 2010-03-23, released 2010-04-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-09-15, with a file datestamp of 2010-09-10.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.172
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene serine/threonine-protein kinase Pim-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIM1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11309
      • see remark 999 (250)
    Domains in SCOPe 2.06: d3ma3a_
  • Chain 'B':
    Compound: pimtide
    Database cross-references and differences (RAF-indexed):
    • PDB 3MA3 (0-6)
  • Heterogens: 01I, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ma3A (A:)
smllskinslahlraapcndlhatklapgkekeplesqyqvgpllgsggfgsvysgirvs
dnlpvaikhvekdrisdwgelpngtrvpmevvllkkvssgfsgvirlldwferpdsfvli
lerpepvqdlfdfitergalqeelarsffwqvleavrhchncgvlhrdikdenilidlnr
gelklidfgsgallkdtvytdfdgtrvysppewiryhryhgrsaavwslgillydmvcgd
ipfehdeeiiggqvffrqrvssecqhlirwclalrpsdrptfeeiqnhpwmqdvllpqet
aeihlhslspgps

    Sequence, based on observed residues (ATOM records): (download) 
    >3ma3A (A:)
qyqvgpllggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvllkkvss
gfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvleavrhc
hncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppewiryhry
hgrsaavwslgillydmvcgdipfehdeeiiggqvffrqrvssecqhlirwclalrpsdr
ptfeeiqnhpwmqdvllpqetaeihlh

  • Chain 'B':
    No sequence available.