PDB entry 3m42

View 3m42 on RCSB PDB site
Description: Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor
Class: transferase
Keywords: SMALL MOLECULE INHIBITOR, ATP-SITE KINASE INHIBITOR, NOVARTIS-PRODUCT NVP-BMA086, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on 2010-03-10, released 2011-03-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-03-23, with a file datestamp of 2011-03-18.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: 0.186
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49137 (2-298)
      • engineered (171)
    Domains in SCOPe 2.07: d3m42a_
  • Heterogens: MG, HGF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3m42A (A:)
gphvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarre
velhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereas
eimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettgekydkscd
mwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewsevseevkmlirnl
lkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsalatmr

    Sequence, based on observed residues (ATOM records): (download) 
    >3m42A (A:)
hvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarreve
lhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereasei
mksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettgekydkscdmw
slgvimyillcgyppfyspgmktrirmgqyefpnpewsevseevkmlirnllkteptqrm
titefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsalatmr