PDB entry 3m17

View 3m17 on RCSB PDB site
Description: Crystal structure of human FcRn with a monomeric peptide inhibitor
Class: immune system/inhibitor
Keywords: IMMUNOGLOBULIN BINDING PROTEIN, Cell membrane, Disulfide bond, Glycoprotein, IgG-binding protein, Immunoglobulin domain, Membrane, Receptor, Transmembrane, Amyloid, Amyloidosis, Disease mutation, Glycation, Immune response, MHC I, Pyrrolidone carboxylic acid, Secreted, IMMUNE SYSTEM-INHIBITOR complex
Deposited on 2010-03-04, released 2010-06-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-08-24, with a file datestamp of 2011-08-19.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.264
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: igg receptor fcrn large subunit p51
  Species: Homo sapiens [TaxId:9606]
  Gene: FCGRT, FCRN
  Database cross-references and differences (RAF-indexed):
  • Uniprot P55899 (Start-266)
• Chain 'B':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (0-98)
  Domains in SCOPe 2.04: d3m17b_
• Chain 'C':
  Compound: igg receptor fcrn large subunit p51
  Species: Homo sapiens [TaxId:9606]
  Gene: FCGRT, FCRN
  Database cross-references and differences (RAF-indexed):
  • Uniprot P55899 (Start-266)
• Chain 'D':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (0-98)
  Domains in SCOPe 2.04: d3m17d_
• Chain 'E':
  Compound: igg receptor fcrn large subunit p51
  Species: Homo sapiens [TaxId:9606]
  Gene: FCGRT, FCRN
  Database cross-references and differences (RAF-indexed):
  • Uniprot P55899 (Start-266)
• Chain 'F':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (0-98)
  Domains in SCOPe 2.04: d3m17f_
• Chain 'G':
  Compound: igg receptor fcrn large subunit p51
  Species: Homo sapiens [TaxId:9606]
  Gene: FCGRT, FCRN
  Database cross-references and differences (RAF-indexed):
  • Uniprot P55899 (Start-266)
• Chain 'H':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (0-98)
  Domains in SCOPe 2.04: d3m17h_
• Chain 'I':
  Compound: monomeric peptide inhibitor
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • PDB 3M17
• Chain 'J':
  Compound: monomeric peptide inhibitor
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • PDB 3M17
• Chain 'K':
  Compound: monomeric peptide inhibitor
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • PDB 3M17
• Chain 'L':
  Compound: monomeric peptide inhibitor
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • PDB 3M17
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3m17B (B:)
  iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
  sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3m17D (D:)
  iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
  sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3m17F (F:)
  iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
  sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3m17H (H:)
  iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
  sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'I':
  No sequence available.
  
  
• Chain 'J':
  No sequence available.
  
  
• Chain 'K':
  No sequence available.
  
  
• Chain 'L':
  No sequence available.