PDB entry 3lzb
View 3lzb on RCSB PDB site
Description: EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor
Class: transferase/transferase inhibitor
Keywords: epidermal growth factor kinase domain, multitargeted small molecule kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2010-03-01, released
2011-03-02
The last revision prior to the SCOPe 2.05 freeze date was dated
2011-03-16, with a file datestamp of
2011-03-11.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.206
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3lzba_ - Chain 'B':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3lzbb_ - Chain 'C':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3lzbc_ - Chain 'D':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3lzbd_ - Chain 'E':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
- Chain 'F':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
- Chain 'G':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
- Heterogens: ITI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3lzbA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgxxxxxxxxxxxx
xxxxxxxxxxxxxxxxxxxxxxxxxxx
Sequence, based on observed residues (ATOM records): (download)
>3lzbA (A:)
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeilde
ayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsr
pkfreliiefskmardpqrylviqg
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3lzbB (B:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgxxxxxxxxxxxx
xxxxxxxxxxxxxxxxxxxxxxxxxxx
Sequence, based on observed residues (ATOM records): (download)
>3lzbB (B:)
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeilde
ayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsr
pkfreliiefskmardpqrylviqg
- Chain 'C':
Sequence, based on SEQRES records: (download)
>3lzbC (C:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgxxxxxxxxxxxx
xxxxxxxxxxxxxxxxxxxxxxxxxxx
Sequence, based on observed residues (ATOM records): (download)
>3lzbC (C:)
lrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreankeildeayvmas
vdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmnyl
edrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvwsygvtv
welmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsrpkfrel
iiefskmardpqrylviqg
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3lzbD (D:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgxxxxxxxxxxxx
xxxxxxxxxxxxxxxxxxxxxxxxxxx
Sequence, based on observed residues (ATOM records): (download)
>3lzbD (D:)
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelrekankeildeayvm
asvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmn
yledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvwsygv
tvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsrpkfr
eliiefskmardpqrylviqg
- Chain 'E':
No sequence available.
- Chain 'F':
No sequence available.
- Chain 'G':
No sequence available.
- Chain 'H':
No sequence available.