PDB entry 3lzb

View 3lzb on RCSB PDB site
Description: EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor
Class: transferase/transferase inhibitor
Keywords: epidermal growth factor kinase domain, multitargeted small molecule kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-03-01, released 2011-03-02
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-03-16, with a file datestamp of 2011-03-11.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.206
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered (252)
    Domains in SCOPe 2.05: d3lzba_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered (252)
    Domains in SCOPe 2.05: d3lzbb_
  • Chain 'C':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered (252)
    Domains in SCOPe 2.05: d3lzbc_
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered (252)
    Domains in SCOPe 2.05: d3lzbd_
  • Chain 'E':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ITI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lzbA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgxxxxxxxxxxxx
xxxxxxxxxxxxxxxxxxxxxxxxxxx

    Sequence, based on observed residues (ATOM records): (download) 
    >3lzbA (A:)
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeilde
ayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsr
pkfreliiefskmardpqrylviqg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lzbB (B:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgxxxxxxxxxxxx
xxxxxxxxxxxxxxxxxxxxxxxxxxx

    Sequence, based on observed residues (ATOM records): (download) 
    >3lzbB (B:)
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeilde
ayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsr
pkfreliiefskmardpqrylviqg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3lzbC (C:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgxxxxxxxxxxxx
xxxxxxxxxxxxxxxxxxxxxxxxxxx

    Sequence, based on observed residues (ATOM records): (download) 
    >3lzbC (C:)
lrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreankeildeayvmas
vdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmnyl
edrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvwsygvtv
welmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsrpkfrel
iiefskmardpqrylviqg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3lzbD (D:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgxxxxxxxxxxxx
xxxxxxxxxxxxxxxxxxxxxxxxxxx

    Sequence, based on observed residues (ATOM records): (download) 
    >3lzbD (D:)
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelrekankeildeayvm
asvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmn
yledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvwsygv
tvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsrpkfr
eliiefskmardpqrylviqg

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.