PDB entry 3lxk
View 3lxk on RCSB PDB site
Description: Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Class: transferase
Keywords: TYK2, JAK3, inflammation, cancer, PAN Inhibitor, ATP-binding, Disease mutation, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, SCID, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on
2010-02-25, released
2010-06-02
The last revision prior to the SCOPe 2.05 freeze date was dated
2010-07-28, with a file datestamp of
2010-07-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.205
AEROSPACI score: 0.44
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase JAK3
Species: Homo sapiens [TaxId:9606]
Gene: JAK3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3lxka_ - Heterogens: MI1, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3lxkA (A:)
mghhhhhhaqlyacqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkql
qhsgpdqqrdfqreiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrh
rarldasrlllyssqickgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpld
kdyyvvrepgqspifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrm
mgcerdvpalsrllelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldm
lwsgsrgcethaftahpegkhhslsfs
Sequence, based on observed residues (ATOM records): (download)
>3lxkA (A:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmvpalsrllelleegqr
lpappacpaevhelmklcwapspqdrpsfsalgpqldml