PDB entry 3lv2

View 3lv2 on RCSB PDB site
Description: Crystal structure of Mycobacterium tuberculosis 7,8-diaminopelargonic acid synthase in complex with substrate analog sinefungin
Class: transferase
Keywords: Rv1568, aminotransferase, bioA, 7, 8-diaminopelargonic acid synthase, Biotin biosynthesis, Pyridoxal phosphate, S-adenosyl-L-methionine, Transferase
Deposited on 2010-02-19, released 2010-08-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-08-25, with a file datestamp of 2010-08-20.
Experiment type: XRAY
Resolution: 2.18 Å
R-factor: 0.181
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: bioA, MT1619, MTCY336.35c, Rv1568
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A4X6 (Start-461)
      • see remark 999 (339)
    Domains in SCOPe 2.06: d3lv2a_
  • Chain 'B':
    Compound: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: bioA, MT1619, MTCY336.35c, Rv1568
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A4X6
      • see remark 999 (339)
    Domains in SCOPe 2.06: d3lv2b_
  • Heterogens: PLP, SFG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lv2A (A:)
mgsshhhhhhssglqgtenlyfqshmaaatggltpeqiiavdgahlwhpyssigreavsp
vvavaahgawltlirdgqpievldamsswwtaihghghpaldqalttqlrvmnhvmfggl
thepaarlakllvditpagldtvffsdsgsvsvevaakmalqywrgrglpgkrrlmtwrg
gyhgdtflamsicdphggmhslwtdvlaaqvfapqvprdydpaysaafeaqlaqhagela
avvvepvvqgaggmrfhdprylhdlrdicrryevllifdeiatgfgrtgalfaadhagvs
pdimcvgkaltggylslaatlctadvahtisagaagalmrgptfmanplacavsvasvel
llgqdwrtritelaagltagldtaralpavtdvrvcgaigviecdrpvdlavatpaaldr
gvwlrpfrnlvyamppyictpaeitqitsamvevarlvgslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3lv2A (A:)
gltpeqiiavdgahlwhpyspvvavaahgawltlirdgqpievldamsswwtaihghghp
aldqalttqlrvmnhvmfgglthepaarlakllvditpagldtvffsdsgsvsvevaakm
alqywrgrglpgkrrlmtwrggyhgdtflamsicdphggmhslwtdvlaaqvfapqvprd
ydpaysaafeaqlaqhagelaavvvepvvqgaggmrfhdprylhdlrdicrryevllifd
eiatgfgrtgalfaadhagvspdimcvgkaltggylslaatlctadvahtisagaalmrg
ptfmanplacavsvasvelllgqdwrtritelaagltagldtaralpavtdvrvcgaigv
iecdrpvdlavatpaaldrgvwlrpfrnlvyamppyictpaeitqitsamvevarlvgsl
p

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lv2B (B:)
mgsshhhhhhssglqgtenlyfqshmaaatggltpeqiiavdgahlwhpyssigreavsp
vvavaahgawltlirdgqpievldamsswwtaihghghpaldqalttqlrvmnhvmfggl
thepaarlakllvditpagldtvffsdsgsvsvevaakmalqywrgrglpgkrrlmtwrg
gyhgdtflamsicdphggmhslwtdvlaaqvfapqvprdydpaysaafeaqlaqhagela
avvvepvvqgaggmrfhdprylhdlrdicrryevllifdeiatgfgrtgalfaadhagvs
pdimcvgkaltggylslaatlctadvahtisagaagalmrgptfmanplacavsvasvel
llgqdwrtritelaagltagldtaralpavtdvrvcgaigviecdrpvdlavatpaaldr
gvwlrpfrnlvyamppyictpaeitqitsamvevarlvgslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3lv2B (B:)
ggltpeqiiavdgahlwhpspvvavaahgawltlirdgqpievldamsswwtaihghghp
aldqalttqlrvmnhvmfgglthepaarlakllvditpagldtvffsdsgsvsvevaakm
alqywrgrglpgkrrlmtwrggyhgdtflamsicdphggdvlaaqvfapqvprdydpays
aafeaqlaqhagelaavvvepvvqgaggmrfhdprylhdlrdicrryevllifdeiatgf
grtgalfaadhagvspdimcvgkaltggylslaatlctadvahtisagaagalmrgptfm
anplacavsvasvelllgqdwrtritelaagltagldtaralpavtdvrvcgaigviecd
rpvdlavatpaaldrgvwlrpfrnlvyamppyictpaeitqitsamvevarlvgs