PDB entry 3lty

View 3lty on RCSB PDB site
Description: Crystal structure of the mutant V182A,I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Class: lyase
Keywords: mutant V182A.I218A, inhibitor BMP, Decarboxylase, Lyase, Pyrimidine biosynthesis
Deposited on 2010-02-16, released 2010-06-16
The last revision prior to the SCOPe 2.01 freeze date was dated 2010-06-16, with a file datestamp of 2010-06-11.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.193
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: orotidine 5'-phosphate decarboxylase
    Species: METHANOTHERMOBACTER THERMAUTOTROPHICUS [TaxId:187420]
    Gene: pyrF, MTH_129
    Database cross-references and differences (RAF-indexed):
    • Uniprot O26232
      • engineered (100)
      • engineered (181)
      • engineered (217)
    Domains in SCOPe 2.01: d3ltya_
  • Chain 'B':
    Compound: orotidine 5'-phosphate decarboxylase
    Species: METHANOTHERMOBACTER THERMAUTOTROPHICUS [TaxId:187420]
    Gene: pyrF, MTH_129
    Database cross-references and differences (RAF-indexed):
    • Uniprot O26232
      • engineered (100)
      • engineered (181)
      • engineered (217)
    Domains in SCOPe 2.01: d3ltyb_
  • Heterogens: BMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ltyA (A:)
mrsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefr
krfgcriiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrev
flltemshpgaemfiqgaadeiarmgvdlgvknyvgpstrperlsrlreiigqdsflisp
gagaqggdpgetlrfadaiivgrsiyladnpaaaaagaiesikdllnp

    Sequence, based on observed residues (ATOM records): (download) 
    >3ltyA (A:)
dvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgcriia
dfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevflltemshp
gaemfiqgaadeiarmgvdlgvknyvgpstrperlsrlreiigqdsflispgagaqggdp
getlrfadaiivgrsiyladnpaaaaagaiesik

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ltyB (B:)
mrsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefr
krfgcriiadfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrev
flltemshpgaemfiqgaadeiarmgvdlgvknyvgpstrperlsrlreiigqdsflisp
gagaqggdpgetlrfadaiivgrsiyladnpaaaaagaiesikdllnp

    Sequence, based on observed residues (ATOM records): (download) 
    >3ltyB (B:)
dvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgcriia
dfkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevflltemshp
gaemfiqgaadeiarmgvdlgvknyvgpstrperlsrlreiigqdsflispgagaqggdp
getlrfadaiivgrsiyladnpaaaaagaiesi