PDB entry 3lpp

View 3lpp on RCSB PDB site
Description: Crystal complex of N-terminal sucrase-isomaltase with kotalanol
Class: hydrolase
Keywords: Glycoside hydrolase family 31, isomaltase, alpha-glucosidase, Cell membrane, Disease mutation, Disulfide bond, Glycoprotein, Glycosidase, Hydrolase, Membrane, Multifunctional enzyme, Polymorphism, Signal-anchor, Sulfation, Transmembrane
Deposited on 2010-02-05, released 2010-03-31
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sucrase-isomaltase
    Species: Homo sapiens [TaxId:9606]
    Gene: SI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14410 (28-897)
      • expression tag (27)
    Domains in SCOPe 2.07: d3lppa1, d3lppa2, d3lppa3, d3lppa4, d3lppa5
  • Chain 'B':
    Compound: Sucrase-isomaltase
    Species: Homo sapiens [TaxId:9606]
    Gene: SI
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3lppb1, d3lppb2, d3lppb3, d3lppb4
  • Chain 'C':
    Compound: Sucrase-isomaltase
    Species: Homo sapiens [TaxId:9606]
    Gene: SI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14410 (28-897)
      • expression tag (27)
    Domains in SCOPe 2.07: d3lppc1, d3lppc2, d3lppc3, d3lppc4, d3lppc5
  • Chain 'D':
    Compound: Sucrase-isomaltase
    Species: Homo sapiens [TaxId:9606]
    Gene: SI
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3lppd1, d3lppd2, d3lppd3, d3lppd4
  • Heterogens: NAG, BMA, MAN, TRS, PEG, CL, KTL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lppA (A:)
rsshhhhhhgefdipttenlyfqsgirrkcpnvlndpvnvrincipeqfptegicaqrgc
cwrpwndslipwcffvdnhgynvqdmtttsigveaklnripsptlfgndinsvlfttqnq
tpnrfrfkitdpnnrryevphqyvkeftgptvsdtlydvkvaqnpfsiqvirksngktlf
dtsigplvysdqylqisarlpsdyiygigeqvhkrfrhdlswktwpiftrdqlpgdnnnn
lyghqtffmciedtsgksfgvflmnsnameifiqptpivtyrvtggildfyillgdtpeq
vvqqyqqlvglpampaywnlgfqlsrwnyksldvvkevvrrnreagipfdtqvtdidyme
dkkdftydqvafnglpqfvqdlhdhgqkyviildpaisigrrangttyatyergntqhvw
inesdgstpiigevwpgltvypdftnpncidwwanecsifhqevqydglwidmnevssfi
qgstkgcnvnklnyppftpdildklmyskticmdavqnwgkqydvhslygysmaiateqa
vqkvfpnkrsfiltrstfagsgrhaahwlgdntasweqmewsitgmlefslfgiplvgad
icgfvaetteelcrrwmqlgafypfsrnhnsdgyehqdpaffgqnsllvkssrqyltiry
tllpflytlfykahvfgetvarpvlhefyedtnswiedteflwgpallitpvlkqgadtv
sayipdaiwydyesgakrpwrkqrvdmylpadkiglhlrggyiipiqepdvtttasrknp
lglivalgenntakgdffwddgetkdtiqngnyilytfsvsnntldivcthssyqegttl
afqtvkilgltdsvtevrvaennqpmnahsnftydasnqvlliadlklnlgrnfsvqw

    Sequence, based on observed residues (ATOM records): (download) 
    >3lppA (A:)
rkcpnvlndpvnvrincipeqfptegicaqrgccwrpwndslipwcffvdnhgynvqdmt
ttsigveaklnripsptlfgndinsvlfttqnqtpnrfrfkitdpnnrryevphqyvkef
tgptvsdtlydvkvaqnpfsiqvirksngktlfdtsigplvysdqylqisarlpsdyiyg
igeqvhkrfrhdlswktwpiftrdqlpgdnnnnlyghqtffmciedtsgksfgvflmnsn
ameifiqptpivtyrvtggildfyillgdtpeqvvqqyqqlvglpampaywnlgfqlsrw
nyksldvvkevvrrnreagipfdtqvtdidymedkkdftydqvafnglpqfvqdlhdhgq
kyviildpaisigrrangttyatyergntqhvwinesdgstpiigevwpgltvypdftnp
ncidwwanecsifhqevqydglwidmnevssfiqgstkgcnvnklnyppftpdildklmy
skticmdavqnwgkqydvhslygysmaiateqavqkvfpnkrsfiltrstfagsgrhaah
wlgdntasweqmewsitgmlefslfgiplvgadicgfvaetteelcrrwmqlgafypfsr
nhnsdgyehqdpaffgqnsllvkssrqyltirytllpflytlfykahvfgetvarpvlhe
fyedtnswiedteflwgpallitpvlkqgadtvsayipdaiwydyesgakrpwrkqrvdm
ylpadkiglhlrggyiipiqepdvtttasrknplglivalgenntakgdffwddgetkdt
iqngnyilytfsvsnntldivcthssyqegttlafqtvkilgltdsvtevrvaennqpmn
ahsnftydasnqvlliadlklnlgrnfsvqw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lppB (B:)
rsshhhhhhgefdipttenlyfqsgirrkcpnvlndpvnvrincipeqfptegicaqrgc
cwrpwndslipwcffvdnhgynvqdmtttsigveaklnripsptlfgndinsvlfttqnq
tpnrfrfkitdpnnrryevphqyvkeftgptvsdtlydvkvaqnpfsiqvirksngktlf
dtsigplvysdqylqisarlpsdyiygigeqvhkrfrhdlswktwpiftrdqlpgdnnnn
lyghqtffmciedtsgksfgvflmnsnameifiqptpivtyrvtggildfyillgdtpeq
vvqqyqqlvglpampaywnlgfqlsrwnyksldvvkevvrrnreagipfdtqvtdidyme
dkkdftydqvafnglpqfvqdlhdhgqkyviildpaisigrrangttyatyergntqhvw
inesdgstpiigevwpgltvypdftnpncidwwanecsifhqevqydglwidmnevssfi
qgstkgcnvnklnyppftpdildklmyskticmdavqnwgkqydvhslygysmaiateqa
vqkvfpnkrsfiltrstfagsgrhaahwlgdntasweqmewsitgmlefslfgiplvgad
icgfvaetteelcrrwmqlgafypfsrnhnsdgyehqdpaffgqnsllvkssrqyltiry
tllpflytlfykahvfgetvarpvlhefyedtnswiedteflwgpallitpvlkqgadtv
sayipdaiwydyesgakrpwrkqrvdmylpadkiglhlrggyiipiqepdvtttasrknp
lglivalgenntakgdffwddgetkdtiqngnyilytfsvsnntldivcthssyqegttl
afqtvkilgltdsvtevrvaennqpmnahsnftydasnqvlliadlklnlgrnfsvqw

    Sequence, based on observed residues (ATOM records): (download) 
    >3lppB (B:)
cpnvlndpvnvrincipeqfptegicaqrgccwrpwndslipwcffvdnhgynvqdmttt
sigveaklnripsptlfgndinsvlfttqnqtpnrfrfkitdpnnrryevphqyvkeftg
ptvsdtlydvkvaqnpfsiqvirksngktlfdtsigplvysdqylqisarlpsdyiygig
eqvhkrfrhdlswktwpiftrdqlpgdnnnnlyghqtffmciedtsgksfgvflmnsnam
eifiqptpivtyrvtggildfyillgdtpeqvvqqyqqlvglpampaywnlgfqlsrwny
ksldvvkevvrrnreagipfdtqvtdidymedkkdftydqvafnglpqfvqdlhdhgqky
viildpaisigrrangttyatyergntqhvwinesdgstpiigevwpgltvypdftnpnc
idwwanecsifhqevqydglwidmnevssfiqgstkgcnvnklnyppftpdildklmysk
ticmdavqnwgkqydvhslygysmaiateqavqkvfpnkrsfiltrstfagsgrhaahwl
gdntasweqmewsitgmlefslfgiplvgadicgfvaetteelcrrwmqlgafypfsrnh
nsdgyehqdpaffgqnsllvkssrqyltirytllpflytlfykahvfgetvarpvlhefy
edtnswiedteflwgpallitpvlkqgadtvsayipdaiwydyesgakrpwrkqrvdmyl
padkiglhlrggyiipiqepdvtttasrknplglivalgenntakgdffwddgetkdtiq
ngnyilytfsvsnntldivcthssyqegttlafqtvkilgltdsvtevrvaennqpmnah
snftydasnqvlliadlklnlgrnfsvqw

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3lppC (C:)
rsshhhhhhgefdipttenlyfqsgirrkcpnvlndpvnvrincipeqfptegicaqrgc
cwrpwndslipwcffvdnhgynvqdmtttsigveaklnripsptlfgndinsvlfttqnq
tpnrfrfkitdpnnrryevphqyvkeftgptvsdtlydvkvaqnpfsiqvirksngktlf
dtsigplvysdqylqisarlpsdyiygigeqvhkrfrhdlswktwpiftrdqlpgdnnnn
lyghqtffmciedtsgksfgvflmnsnameifiqptpivtyrvtggildfyillgdtpeq
vvqqyqqlvglpampaywnlgfqlsrwnyksldvvkevvrrnreagipfdtqvtdidyme
dkkdftydqvafnglpqfvqdlhdhgqkyviildpaisigrrangttyatyergntqhvw
inesdgstpiigevwpgltvypdftnpncidwwanecsifhqevqydglwidmnevssfi
qgstkgcnvnklnyppftpdildklmyskticmdavqnwgkqydvhslygysmaiateqa
vqkvfpnkrsfiltrstfagsgrhaahwlgdntasweqmewsitgmlefslfgiplvgad
icgfvaetteelcrrwmqlgafypfsrnhnsdgyehqdpaffgqnsllvkssrqyltiry
tllpflytlfykahvfgetvarpvlhefyedtnswiedteflwgpallitpvlkqgadtv
sayipdaiwydyesgakrpwrkqrvdmylpadkiglhlrggyiipiqepdvtttasrknp
lglivalgenntakgdffwddgetkdtiqngnyilytfsvsnntldivcthssyqegttl
afqtvkilgltdsvtevrvaennqpmnahsnftydasnqvlliadlklnlgrnfsvqw

    Sequence, based on observed residues (ATOM records): (download) 
    >3lppC (C:)
rkcpnvlndpvnvrincipeqfptegicaqrgccwrpwndslipwcffvdnhgynvqdmt
ttsigveaklnripsptlfgndinsvlfttqnqtpnrfrfkitdpnnrryevphqyvkef
tgptvsdtlydvkvaqnpfsiqvirksngktlfdtsigplvysdqylqisarlpsdyiyg
igeqvhkrfrhdlswktwpiftrdqlpgdnnnnlyghqtffmciedtsgksfgvflmnsn
ameifiqptpivtyrvtggildfyillgdtpeqvvqqyqqlvglpampaywnlgfqlsrw
nyksldvvkevvrrnreagipfdtqvtdidymedkkdftydqvafnglpqfvqdlhdhgq
kyviildpaisigrrangttyatyergntqhvwinesdgstpiigevwpgltvypdftnp
ncidwwanecsifhqevqydglwidmnevssfiqgstkgcnvnklnyppftpdildklmy
skticmdavqnwgkqydvhslygysmaiateqavqkvfpnkrsfiltrstfagsgrhaah
wlgdntasweqmewsitgmlefslfgiplvgadicgfvaetteelcrrwmqlgafypfsr
nhnsdgyehqdpaffgqnsllvkssrqyltirytllpflytlfykahvfgetvarpvlhe
fyedtnswiedteflwgpallitpvlkqgadtvsayipdaiwydyesgakrpwrkqrvdm
ylpadkiglhlrggyiipiqepdvtttasrknplglivalgenntakgdffwddgetkdt
iqngnyilytfsvsnntldivcthssyqegttlafqtvkilgltdsvtevrvaennqpmn
ahsnftydasnqvlliadlklnlgrnfsvqw

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3lppD (D:)
rsshhhhhhgefdipttenlyfqsgirrkcpnvlndpvnvrincipeqfptegicaqrgc
cwrpwndslipwcffvdnhgynvqdmtttsigveaklnripsptlfgndinsvlfttqnq
tpnrfrfkitdpnnrryevphqyvkeftgptvsdtlydvkvaqnpfsiqvirksngktlf
dtsigplvysdqylqisarlpsdyiygigeqvhkrfrhdlswktwpiftrdqlpgdnnnn
lyghqtffmciedtsgksfgvflmnsnameifiqptpivtyrvtggildfyillgdtpeq
vvqqyqqlvglpampaywnlgfqlsrwnyksldvvkevvrrnreagipfdtqvtdidyme
dkkdftydqvafnglpqfvqdlhdhgqkyviildpaisigrrangttyatyergntqhvw
inesdgstpiigevwpgltvypdftnpncidwwanecsifhqevqydglwidmnevssfi
qgstkgcnvnklnyppftpdildklmyskticmdavqnwgkqydvhslygysmaiateqa
vqkvfpnkrsfiltrstfagsgrhaahwlgdntasweqmewsitgmlefslfgiplvgad
icgfvaetteelcrrwmqlgafypfsrnhnsdgyehqdpaffgqnsllvkssrqyltiry
tllpflytlfykahvfgetvarpvlhefyedtnswiedteflwgpallitpvlkqgadtv
sayipdaiwydyesgakrpwrkqrvdmylpadkiglhlrggyiipiqepdvtttasrknp
lglivalgenntakgdffwddgetkdtiqngnyilytfsvsnntldivcthssyqegttl
afqtvkilgltdsvtevrvaennqpmnahsnftydasnqvlliadlklnlgrnfsvqw

    Sequence, based on observed residues (ATOM records): (download) 
    >3lppD (D:)
lndpvnvrincipeqfptegicaqrgccwrpwndslipwcffvdnhgynvqdmtttsigv
eaklnripsptlfgndinsvlfttqnqtpnrfrfkitdpnnrryevphqyvkeftgptvs
dtlydvkvaqnpfsiqvirksngktlfdtsigplvysdqylqisarlpsdyiygigeqvh
krfrhdlswktwpiftrdqlpgdnnnnlyghqtffmciedtsgksfgvflmnsnameifi
qptpivtyrvtggildfyillgdtpeqvvqqyqqlvglpampaywnlgfqlsrwnyksld
vvkevvrrnreagipfdtqvtdidymedkkdftydqvafnglpqfvqdlhdhgqkyviil
dpaisigrryatyergntqhvwinesdgstpiigevwpgltvypdftnpncidwwanecs
ifhqevqydglwidmnevssfiqgstkgcnvnklnyppftpdildklmyskticmdavqn
wgkqydvhslygysmaiateqavqkvfpnkrsfiltrstfagsgrhaahwlgdntasweq
mewsitgmlefslfgiplvgadicgfvaetteelcrrwmqlgafypfsrnhnsdgyehqd
paffgqnsllvkssrqyltirytllpflytlfykahvfgetvarpvlhefyedtnswied
teflwgpallitpvlkqgadtvsayipdaiwydyesgakrpwrkqrvdmylpadkiglhl
rggyiipiqepdvtttasrknplglivalgenntakgdffwddgetkdtiqngnyilytf
svsnntldivcthssyqegttlafqtvkilgltdsvtevrvaehsnftydasnqvlliad
lklnlgrnfsvqw