PDB entry 3lok

View 3lok on RCSB PDB site
Description: Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393
Class: transferase/transferase inhibitor
Keywords: Src kinase domain, drug resistance, irreversible inhibitor, covalent inhibitor, PD168393, ATP-binding, Kinase, Lipoprotein, Myristate, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Tyrosine-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-02-04, released 2010-12-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-12-22, with a file datestamp of 2010-12-17.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: 0.225
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC, v-Src sarcoma viral oncogene
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (90)
      • engineered mutation (97)
    Domains in SCOPe 2.06: d3loka_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC, v-Src sarcoma viral oncogene
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered mutation (90)
      • engineered mutation (97)
    Domains in SCOPe 2.06: d3lokb_
  • Heterogens: DJK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lokA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >3lokA (A:)
kdaweipreslrlevklgfgevwmgtwngttrvaiktleaqvmkklrheklvqlyavvse
epiyivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraan
ilvgenlvckvadfglarlpikwtapeaalygrftiksdvwsfgilltelttkgrvpypg
mvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstep
qyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lokB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >3lokB (B:)
daweipreslrlevklgqggevwmgtwngttrvaiktlkmkklrheklvqlyavvseepi
yivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraanilv
genlvckvadfglpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrev
ldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpge
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