PDB entry 3lok
View 3lok on RCSB PDB site
Description: Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393
Class: transferase/transferase inhibitor
Keywords: Src kinase domain, drug resistance, irreversible inhibitor, covalent inhibitor, PD168393, ATP-binding, Kinase, Lipoprotein, Myristate, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Tyrosine-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2010-02-04, released
2010-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated
2010-12-22, with a file datestamp of
2010-12-17.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: 0.225
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Gallus gallus [TaxId:9031]
Gene: SRC, v-Src sarcoma viral oncogene
Database cross-references and differences (RAF-indexed):
- Uniprot P00523 (Start-285)
- engineered mutation (90)
- engineered mutation (97)
Domains in SCOPe 2.08: d3loka_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Gallus gallus [TaxId:9031]
Gene: SRC, v-Src sarcoma viral oncogene
Database cross-references and differences (RAF-indexed):
- Uniprot P00523 (Start-285)
- engineered mutation (90)
- engineered mutation (97)
Domains in SCOPe 2.08: d3lokb_ - Heterogens: DJK, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3lokA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>3lokA (A:)
kdaweipreslrlevklgfgevwmgtwngttrvaiktleaqvmkklrheklvqlyavvse
epiyivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraan
ilvgenlvckvadfglarlpikwtapeaalygrftiksdvwsfgilltelttkgrvpypg
mvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstep
qyqpgenl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3lokB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivmeymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>3lokB (B:)
daweipreslrlevklgqggevwmgtwngttrvaiktlkmkklrheklvqlyavvseepi
yivmeymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraanilv
genlvckvadfglpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrev
ldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpge
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