PDB entry 3lmy

View 3lmy on RCSB PDB site
Description: The Crystal Structure of beta-hexosaminidase B in complex with Pyrimethamine
Class: hydrolase
Keywords: 6-stranded anti-parallel beta-sheet, TIM barrel, Disease mutation, Disulfide bond, Gangliosidosis, Glycoprotein, Glycosidase, Hydrolase, Lysosome
Deposited on 2010-02-01, released 2011-02-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-hexosaminidase subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3lmya1, d3lmya2
  • Chain 'B':
    Compound: Beta-hexosaminidase subunit beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3lmyb1, d3lmyb2
  • Heterogens: NDG, NAG, CP6, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lmyA (A:)
melcglglprppmllalllatllaamlalltqvalvvqvaeaarapsvsakpgpalwplp
lsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfykwhhepaefqa
ktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvy
qdsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivd
dqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgk
gqkdlltpcysrqnkldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkc
wesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgti
vevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkql
figgeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmverg
iaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >3lmyA (A:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyiftqvqqll
vsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtft
inestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqs
itfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltp
cysdsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrq
kgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeel
srvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyv
datnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lmyB (B:)
melcglglprppmllalllatllaamlalltqvalvvqvaeaarapsvsakpgpalwplp
lsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfykwhhepaefqa
ktqvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvy
qdsygtftinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivd
dqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgk
gqkdlltpcysrqnkldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkc
wesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgti
vevwkdsaypeelsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkql
figgeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmverg
iaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >3lmyB (B:)
palwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgtqvqql
lvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqdsygtf
tinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyq
sitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdllt
pcysdsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmr
qkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypee
lsrvtasgfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgey
vdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn