SCOPe 2.03: Structural Classification of Proteins

PDB entry 3lj7

View 3lj7 on RCSB PDB site
Description: 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with Carbamate inhibitor URB597
Class: hydrolase
Keywords: protein-inhibitor complex, FAAH, fatty acid amide hydrolase, carbamate, inhibitor, covalent, Endoplasmic reticulum, Golgi apparatus, Membrane, Transmembrane, HYDROLASE
Deposited on 2010-01-25, released 2010-06-09
The last revision prior to the SCOPe 2.03 freeze date was dated 2010-07-28, with a file datestamp of 2010-07-23.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.178
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: fatty-acid amide hydrolase 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Faah, Faah1
Database cross-references and differences (RAF-indexed):
- Uniprot P97612
  - engineered (185)
  - engineered (187)
  - engineered (370)
  - engineered (428)
  - engineered (484)
  - engineered (488)
Domains in SCOPe 2.03: d3lj7a_
Chain 'B':
Compound: fatty-acid amide hydrolase 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Faah, Faah1
Database cross-references and differences (RAF-indexed):
- Uniprot P97612
  - engineered (185)
  - engineered (187)
  - engineered (370)
  - engineered (428)
  - engineered (484)
  - engineered (488)
Domains in SCOPe 2.03: d3lj7b_
Heterogens: OHO, CL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3lj7A (A:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

Sequence, based on observed residues (ATOM records): (download)

>3lj7A (A:)
grqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgels
peavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghds
tlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssk
spggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvyg
qtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyet
dnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnf
kgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheie
myrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttv
taeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlm
tpqkq

Chain 'B':
Sequence, based on SEQRES records: (download)

>3lj7B (B:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

Sequence, based on observed residues (ATOM records): (download)

>3lj7B (B:)
tgrqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgel
speavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghd
stlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkss
kspggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvy
gqtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyye
tdnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqn
fkgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqhei
emyrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvtt
vtaeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveql
mtpqkqp