SCOPe 2.08: Structural Classification of Proteins

PDB entry 3lj6

View 3lj6 on RCSB PDB site
Description: 3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE DRUG-LIKE UREA INHIBITOR PF-3845 at 2.42A RESOLUTION
Class: hydrolase
Keywords: protein-inhibitor complex, FAAH, fatty acid amide hydrolase, urea, inhibitor, covalent, Endoplasmic reticulum, Golgi apparatus, Membrane, Transmembrane, HYDROLASE
Deposited on 2010-01-25, released 2010-06-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-12-14, with a file datestamp of 2011-12-09.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: 0.163
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: fatty-acid amide hydrolase 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Faah, Faah1
Database cross-references and differences (RAF-indexed):
- Uniprot P97612
  - engineered (185)
  - engineered (187)
  - engineered (370)
  - engineered (428)
  - engineered (484)
  - engineered (488)
Domains in SCOPe 2.08: d3lj6a_
Chain 'B':
Compound: fatty-acid amide hydrolase 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Faah, Faah1
Database cross-references and differences (RAF-indexed):
- Uniprot P97612
  - engineered (185)
  - engineered (187)
  - engineered (370)
  - engineered (428)
  - engineered (484)
  - engineered (488)
Domains in SCOPe 2.08: d3lj6b_
Heterogens: PIX, CL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3lj6A (A:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

Sequence, based on observed residues (ATOM records): (download)

>3lj6A (A:)
rqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgelsp
eavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghdst
lglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssks
pggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvygq
tavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyetd
nytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnfk
gdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheiem
yrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttvt
aeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlmt
p

Chain 'B':
Sequence, based on SEQRES records: (download)

>3lj6B (B:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

Sequence, based on observed residues (ATOM records): (download)

>3lj6B (B:)
tgrqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgel
speavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghd
stlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkss
kspggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvy
gqtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyye
tdnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqn
fkgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqhei
emyrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvtt
vtaeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveql
mtp