PDB entry 3lea
View 3lea on RCSB PDB site
Description: Crystal structure of the catalytic domain of TACE with Isoindolinone-biphenyl-hydantoin inhibitor
Class: hydrolase
Keywords: glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, transmembrane, zymogen, hydrolase
Deposited on
2010-01-14, released
2010-12-08
The last revision prior to the SCOPe 2.08 freeze date was dated
2010-12-08, with a file datestamp of
2010-12-03.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.176
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Disintegrin and metalloproteinase domain-containing protein 17
Species: Homo sapiens [TaxId:9606]
Gene: ADAM17, CSVP, TACE
Database cross-references and differences (RAF-indexed):
- Uniprot P78536
- engineered (51)
- engineered (138)
- engineered (237)
Domains in SCOPe 2.08: d3leaa_ - Chain 'B':
Compound: Disintegrin and metalloproteinase domain-containing protein 17
Species: Homo sapiens [TaxId:9606]
Gene: ADAM17, CSVP, TACE
Database cross-references and differences (RAF-indexed):
- Uniprot P78536 (0-End)
- engineered (51)
- engineered (138)
- engineered (237)
Domains in SCOPe 2.08: d3leab_ - Heterogens: Z93, ZN, IPA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3leaA (A:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkgshhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3leaA (A:)
dpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgyg
iqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclah
lftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygktilt
keadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskq
siyktieskaqecfqers
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3leaB (B:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkgshhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3leaB (B:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersn