PDB entry 3lea

View 3lea on RCSB PDB site
Description: Crystal structure of the catalytic domain of TACE with Isoindolinone-biphenyl-hydantoin inhibitor
Class: hydrolase
Keywords: glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, transmembrane, zymogen, hydrolase
Deposited on 2010-01-14, released 2010-12-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-12-08, with a file datestamp of 2010-12-03.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.176
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Disintegrin and metalloproteinase domain-containing protein 17
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM17, CSVP, TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (51)
      • engineered (138)
      • engineered (237)
    Domains in SCOPe 2.08: d3leaa_
  • Chain 'B':
    Compound: Disintegrin and metalloproteinase domain-containing protein 17
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM17, CSVP, TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536 (0-End)
      • engineered (51)
      • engineered (138)
      • engineered (237)
    Domains in SCOPe 2.08: d3leab_
  • Heterogens: Z93, ZN, IPA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3leaA (A:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3leaA (A:)
dpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgyg
iqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclah
lftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygktilt
keadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskq
siyktieskaqecfqers

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3leaB (B:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3leaB (B:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersn