PDB entry 3lct

View 3lct on RCSB PDB site
Description: Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain
Class: transferase
Keywords: kinase catalytic domain, ATP-binding, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, Receptor, Transmembrane, Tyrosine-protein kinase, TRANSFERASE
Deposited on 2010-01-11, released 2010-08-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-09-08, with a file datestamp of 2010-09-03.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.207
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered (214)
    Domains in SCOPe 2.07: d3lcta_
  • Heterogens: GOL, ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lctA (A:)
gamgselqspeyklsklrtstimtdynpnycfagktssisdlkevprknitlirglghga
fgevyegqvsgmpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvs
lqslprfillelmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfi
hrdiaarnclltcpgpgrvakigdfgmardiyragyyrkggcamlpvkwmppeafmegif
tsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcw
qhqpedrpnfaiilerieyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >3lctA (A:)
npnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktl
pevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretr
prpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfg
mardiyragyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympyps
ksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdv
intalpie