PDB entry 3lcs

View 3lcs on RCSB PDB site
Description: Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain
Class: transferase
Keywords: kinase domain, ATP-binding, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, Receptor, Transmembrane, Tyrosine-protein kinase, TRANSFERASE
Deposited on 2010-01-11, released 2010-08-04
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-09-15, with a file datestamp of 2010-09-10.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.196
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered (214)
    Domains in SCOPe 2.06: d3lcsa_
  • Heterogens: STU, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lcsA (A:)
gamgselqspeyklsklrtstimtdynpnycfagktssisdlkevprknitlirglghga
fgevyegqvsgmpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvs
lqslprfillelmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfi
hrdiaarnclltcpgpgrvakigdfgmardiyragyyrkggcamlpvkwmppeafmegif
tsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcw
qhqpedrpnfaiilerieyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >3lcsA (A:)
ycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktlpev
cseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprp
sqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmar
diyragyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksn
qevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvint
alpi