PDB entry 3lcp

View 3lcp on RCSB PDB site
Description: Crystal structure of the carbohydrate recognition domain of LMAN1 in complex with MCFD2
Class: protein binding
Keywords: ER-GOLGI TRANSPORT, GLYCOPROTEIN SORTING, DISEASE MUTATION, SECRETORY PATHWAY, PROTEIN TRANSPORT, COAGULATION FACTOR DEFICIENCY, Disulfide bond, Endoplasmic reticulum, Golgi apparatus, Lectin, Membrane, Polymorphism, Transmembrane, Transport, Calcium, PROTEIN BINDING
Deposited on 2010-01-11, released 2010-01-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-04-28, with a file datestamp of 2010-04-23.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.199
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein ERGIC-53
    Species: Homo sapiens [TaxId:9606]
    Gene: ERGIC53, F5F8D, LMAN1, LMAN1 (AMINO ACIDS 32-277)
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3lcpa_
  • Chain 'B':
    Compound: Protein ERGIC-53
    Species: Homo sapiens [TaxId:9606]
    Gene: ERGIC53, F5F8D, LMAN1, LMAN1 (AMINO ACIDS 32-277)
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3lcpb_
  • Chain 'C':
    Compound: multiple coagulation factor deficiency protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MCFD2, MCFD2 (AMINO ACIDS 58-146), SDNSF
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: multiple coagulation factor deficiency protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MCFD2, MCFD2 (AMINO ACIDS 58-146), SDNSF
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lcpA (A:)
mgvggdpavalphrrfeykysfkgphlvqsdgtvpfwahagnaipssdqirvapslksqr
gsvwtktkaafenwevevtfrvtgrgrigadglaiwyaenqglegpvfgsadlwngvgif
fdsfdndgkknnpaiviignngqihydhqndgasqalascqrdfrnkpypvrakityyqn
tltvminngftpdkndyefcakvenmiipaqghfgisaatggladdhdvlsfltfqltep
gkepptp

    Sequence, based on observed residues (ATOM records): (download) 
    >3lcpA (A:)
lphrrfeykysfkgphlvqsdgtvpfwahagnaipssdqirvapslksqrgsvwtktkaa
fenwevevtfrvtgrgrigadglaiwyaenqglegpvfgsadlwngvgiffdsfdndgkk
nnpaiviignngqihydhqndgasqalascqrdfrnkpypvrakityyqntltvminngf
tpdkndyefcakvenmiipaqghfgisaatggladdhdvlsfltfqltepgkep

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lcpB (B:)
mgvggdpavalphrrfeykysfkgphlvqsdgtvpfwahagnaipssdqirvapslksqr
gsvwtktkaafenwevevtfrvtgrgrigadglaiwyaenqglegpvfgsadlwngvgif
fdsfdndgkknnpaiviignngqihydhqndgasqalascqrdfrnkpypvrakityyqn
tltvminngftpdkndyefcakvenmiipaqghfgisaatggladdhdvlsfltfqltep
gkepptp

    Sequence, based on observed residues (ATOM records): (download) 
    >3lcpB (B:)
lphrrfeykysfkgphlvqsdgtvpfwahagnaipssdqirvapslksqrgsvwtktkaa
fenwevevtfrvtgrgrigadglaiwyaenqglegpvfgsadlwngvgiffdsfdndgkk
nnpaiviignngqihydhqndgasqalascqrdfrnkpypvrakityyqntltvminngf
tpdkndyefcakvenmiipaqghfgisaatggladdhdvlsfltfqltepgkep

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.