PDB entry 3l9m

View 3l9m on RCSB PDB site
Description: Crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 18
Class: transferase/transferase inhibitor
Keywords: PKB, INHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-01-05, released 2011-01-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-01-19, with a file datestamp of 2011-01-14.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.223
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17612 (Start-350)
      • engineered mutation (123)
      • engineered mutation (173)
      • engineered mutation (181)
    Domains in SCOPe 2.07: d3l9ma_
  • Chain 'B':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17612 (Start-350)
      • engineered mutation (123)
      • engineered mutation (173)
      • engineered mutation (181)
    Domains in SCOPe 2.07: d3l9mb_
  • Chain 'C':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PKIA, PRKACN1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PKIA, PRKACN1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: L9M, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3l9mA (A:)
mgnaaaakkgseqesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvml
vkhketgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymv
meyapggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgy
ikvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppff
adqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfat
tdwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records): (download) 
    >3l9mA (A:)
eqesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhya
mkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyapggemfs
hlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgyikvtdfgfakr
vkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyeki
vsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkv
eapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3l9mB (B:)
mgnaaaakkgseqesvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvml
vkhketgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymv
meyapggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgy
ikvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppff
adqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfat
tdwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

    Sequence, based on observed residues (ATOM records): (download) 
    >3l9mB (B:)
esvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhyamk
ildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyapggemfshl
rrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgyikvtdfgfakrvk
grtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivs
gkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkvea
pfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.