PDB entry 3l9j

View 3l9j on RCSB PDB site
Description: Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex
Class: immune system
Keywords: TNF-alpha, antagonist, in vitro selection, Cell membrane, Cytokine, Disulfide bond, Glycoprotein, Lipoprotein, Secreted, Signal-anchor, Transmembrane, IMMUNE SYSTEM
Deposited on 2010-01-05, released 2010-02-23
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-02-26, with a file datestamp of 2014-02-21.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.175
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: TNFalpha
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • PDB 3L9J (0-133)
    Domains in SCOPe 2.06: d3l9jc_
  • Chain 'T':
    Compound: Tumor necrosis factor, soluble form
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3l9jt_
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3l9jC (C:)
    lqtvclkgtkhmkcflaftqtktfheasedcisrggtlstpqtgsendalyeylrqsvgn
    eaeiwlglnkrwsryfwvdmtgtriayknwehssdaqpdpsnwencavlsgaangkwfgk
    rcrdqlpyicqfgi
    

    Sequence, based on observed residues (ATOM records): (download)
    >3l9jC (C:)
    lqtvclhmkcflaftqtktfheasedcisrggtlstpqtgsendalyeylrqsvgneaei
    wlglnkrwsryfwvdmtgtriayknwehssdaqpdpsnwencavlsgaangkwfgkrcrd
    qlpyicqfgi
    

  • Chain 'T':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3l9jT (T:)
    sdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfkgqg
    cpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvfqlek
    gdrlsaeinrpdyldfaesgqvyfgiial